5 - gastric secretion Flashcards
what is the role of fundus
storage
what is the role of the body
storage, mucous, secreoin of hcl, secreiona of pepsinogne, secreion of hte intrinsic facros
what is the role of the anturm
mixing/grinding
gastrin
what are the cellular composition of gasatic glands
surface mucous
paritel cell
cheif cell
what is the fucntio of the gastic pit
openign of the gastic glend wher the muocus is secred
what is the cell in gastic pit
surface mucous cell
wha tis the role of the chief cell
secrete pepsinogens
what is the role of the parietal cells
hcl and intrinsic factor secretions
what is the ph of teh stomac
less than 2
what acid is in the sotmac
hcl
where is the role of hte bichomane choline exchanges
exhcnes bicarbone for clodiren,
wher is teh bicarbone made
from reacting h20 with c02 from blood
what is the role of teh protm posttium atp ase pum
excens potsium into the clel with pronts out to form hcl
how does hte cl leave the cell
leaky channels
what happens to the blood ph from hcl realse ;after eating
slight increa whihc slowling neutlies out
what chemcial caues protons to be relaed
gastrin, histamine, prosaglandins, acetylcholine
what recetor does gastrin atttach to and what doe sit relase
cckb to reasle ca
what protein kinase is used to transport calcium
pkc
what recpeort is used for histamne and what happens
h2 recport, turns atp to camp
what recport is used for aceklty coline and what is relased
m3 to relae ca
what isthe role of protsalgindes in gastric acid section
to act as a inhibitor for gastric acid as work on ac
what do pritne kinases work on
protin potisum pump
what type of histeome is associed with allergy
h1
what is the cause of a peptic ulcer
nsaids, due to decreisng prostlgy producton
h pylori bacteria
waht type of prinetikes is pka
camp
what is treatment for gastic acid desction
hcl inhibtion
symptoms of stomac ulcer
buring pina, fatique, heartburn loss of appide, nausea, vomming, loading, burning, weightooss, dull pain
what sithre role of alcium carbionate and other carbionate compounds
to reduce hcl
what drug clasess inhib hcl secteroin
proton pump inhibirots
muscarinic antagonists
h2 receptor antagonists
h2 receptor antagonis examples
cimestine and ranitidine
muscarinic antagons
pirenzepine m3 selectiveq and atropine (genrelly)
proton pump inhibitors
omeprazole and lansoprazole
effect of heplocpalri
causes isnlfatio in mucosa, and leads to ulcer due to it producing high amoiuntes of nh3 which combines with h+ to produce nh4
treatment for ulcer
2 high dose antibioitc an da ppi for 1 week
what percent fo peple is the medical treatment for ulcerse effeciv
90%
what mechanism control gastic acid secteiorn
neurocine, endocrine adn paracrine
wher is gastin relased from
g cells
what is teh effect of the vagus nerve in cephalic phase
trigger relaed of ach and g cells to release gastine which work on partilc cells
whawt isthe the effect of gasatrin an ach on ecl cells in celpahic phase
release hsitamine
cephalic phase
wher ehte body gets in prepearion ot start eating as a result of the smell/taste of food
what is the gastric phase
when the food arrives in the stomach
what nerve is stimuled by the digestein of food
valgs, relaing ach,
what happnes whenn peptides are foundin the stomach
g cells relasee gastrin
what do gastic adn ach caues relaed
histomin by ecl cells
wath i the inteinal phase
when the food eneter the intes ad sotmac acid is redued
waht is reled is ther eis acid in the duodeun
secretin
what happesn to gastin secton if secretin ins relaed
it is decreaed
what happnes if ther is fat in the duoent
gip is realed
decreae gasting stiminum of partial cells
what happnes to gastin section if gip is relaed
decreased, decrein ghcl section
what are enterogastrones
hormoesn relased in resornes to acid, hypertonic soluntiosn, fatty acids, or monoglcries in the duodenum
what is the role of the splannich reflex (enterogatric)
to prevent futher acid buildup in the duodeunm by reducing gastrin secreation
how do enterogastornes work
inhibit gastric acid secretion
reduce gastic emptying - inhigbitng hte motilty pyloric spinger
what are exampes of enteroglas
secretin, cholecystokinin, gip
what are pepsingsi ph aciteved at
neutrolpph
what are peotons roel
incactie enyes to turn int pepsings at pnurelph
when are pepsinges relaed
when ph is less then 3
whae are pepsins reacived
when ph is abvoe 3
where sit he intreici factor relaed form
pariteial cells
what is the role of the gastic mucs
cytoproteive role
protens muclas surfce from emchail injury
nuertal ph, protences agisn gastic acid corrosion and pepsin digestion
wher is gatic mcuus relaed from
srucface epithl cells and mucus neck clels
what is main role of gip
slows down the digestion of fats to help maintain blood glucose level by reducing gastrin secretion
role of somatatin
shud down acid secrtion by decrasing gasting, and histamine secreaion and inhibits pepsingoen section
wher is somataisn secred form
d cells in stoahc
