5 - gastric secretion Flashcards

1
Q

what is the role of fundus

A

storage

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2
Q

what is the role of the body

A

storage, mucous, secreoin of hcl, secreiona of pepsinogne, secreion of hte intrinsic facros

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3
Q

what is the role of the anturm

A

mixing/grinding
gastrin

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4
Q

what are the cellular composition of gasatic glands

A

surface mucous
paritel cell
cheif cell

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5
Q

what is the fucntio of the gastic pit

A

openign of the gastic glend wher the muocus is secred

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6
Q

what is the cell in gastic pit

A

surface mucous cell

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7
Q

wha tis the role of the chief cell

A

secrete pepsinogens

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8
Q

what is the role of the parietal cells

A

hcl and intrinsic factor secretions

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9
Q

what is the ph of teh stomac

A

less than 2

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10
Q

what acid is in the sotmac

A

hcl

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11
Q

where is the role of hte bichomane choline exchanges

A

exhcnes bicarbone for clodiren,

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12
Q

wher is teh bicarbone made

A

from reacting h20 with c02 from blood

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13
Q

what is the role of teh protm posttium atp ase pum

A

excens potsium into the clel with pronts out to form hcl

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14
Q

how does hte cl leave the cell

A

leaky channels

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15
Q

what happens to the blood ph from hcl realse ;after eating

A

slight increa whihc slowling neutlies out

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16
Q

what chemcial caues protons to be relaed

A

gastrin, histamine, prosaglandins, acetylcholine

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17
Q

what recetor does gastrin atttach to and what doe sit relase

A

cckb to reasle ca

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18
Q

what protein kinase is used to transport calcium

A

pkc

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19
Q

what recpeort is used for histamne and what happens

A

h2 recport, turns atp to camp

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20
Q

what recport is used for aceklty coline and what is relased

A

m3 to relae ca

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21
Q

what isthe role of protsalgindes in gastric acid section

A

to act as a inhibitor for gastric acid as work on ac

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22
Q

what do pritne kinases work on

A

protin potisum pump

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23
Q

what type of histeome is associed with allergy

A

h1

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24
Q

what is the cause of a peptic ulcer

A

nsaids, due to decreisng prostlgy producton
h pylori bacteria

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25
Q

waht type of prinetikes is pka

A

camp

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26
Q

what is treatment for gastic acid desction

A

hcl inhibtion

27
Q

symptoms of stomac ulcer

A

buring pina, fatique, heartburn loss of appide, nausea, vomming, loading, burning, weightooss, dull pain

28
Q

what sithre role of alcium carbionate and other carbionate compounds

A

to reduce hcl

29
Q

what drug clasess inhib hcl secteroin

A

proton pump inhibirots
muscarinic antagonists
h2 receptor antagonists

30
Q

h2 receptor antagonis examples

A

cimestine and ranitidine

31
Q

muscarinic antagons

A

pirenzepine m3 selectiveq and atropine (genrelly)

32
Q

proton pump inhibitors

A

omeprazole and lansoprazole

33
Q

effect of heplocpalri

A

causes isnlfatio in mucosa, and leads to ulcer due to it producing high amoiuntes of nh3 which combines with h+ to produce nh4

34
Q

treatment for ulcer

A

2 high dose antibioitc an da ppi for 1 week

35
Q

what percent fo peple is the medical treatment for ulcerse effeciv

A

90%

36
Q

what mechanism control gastic acid secteiorn

A

neurocine, endocrine adn paracrine

37
Q

wher is gastin relased from

A

g cells

38
Q

what is teh effect of the vagus nerve in cephalic phase

A

trigger relaed of ach and g cells to release gastine which work on partilc cells

39
Q

whawt isthe the effect of gasatrin an ach on ecl cells in celpahic phase

A

release hsitamine

40
Q

cephalic phase

A

wher ehte body gets in prepearion ot start eating as a result of the smell/taste of food

41
Q

what is the gastric phase

A

when the food arrives in the stomach

42
Q

what nerve is stimuled by the digestein of food

A

valgs, relaing ach,

43
Q

what happnes whenn peptides are foundin the stomach

A

g cells relasee gastrin

44
Q

what do gastic adn ach caues relaed

A

histomin by ecl cells

45
Q

wath i the inteinal phase

A

when the food eneter the intes ad sotmac acid is redued

46
Q

waht is reled is ther eis acid in the duodeun

A

secretin

47
Q

what happesn to gastin secton if secretin ins relaed

A

it is decreaed

48
Q

what happnes if ther is fat in the duoent

A

gip is realed
decreae gasting stiminum of partial cells

49
Q

what happnes to gastin section if gip is relaed

A

decreased, decrein ghcl section

50
Q

what are enterogastrones

A

hormoesn relased in resornes to acid, hypertonic soluntiosn, fatty acids, or monoglcries in the duodenum

51
Q

what is the role of the splannich reflex (enterogatric)

A

to prevent futher acid buildup in the duodeunm by reducing gastrin secreation

52
Q

how do enterogastornes work

A

inhibit gastric acid secretion
reduce gastic emptying - inhigbitng hte motilty pyloric spinger

53
Q

what are exampes of enteroglas

A

secretin, cholecystokinin, gip

54
Q

what are pepsingsi ph aciteved at

A

neutrolpph

55
Q

what are peotons roel

A

incactie enyes to turn int pepsings at pnurelph

56
Q

when are pepsinges relaed

A

when ph is less then 3

57
Q

whae are pepsins reacived

A

when ph is abvoe 3

58
Q

where sit he intreici factor relaed form

A

pariteial cells

59
Q

what is the role of the gastic mucs

A

cytoproteive role
protens muclas surfce from emchail injury
nuertal ph, protences agisn gastic acid corrosion and pepsin digestion

60
Q

wher is gatic mcuus relaed from

A

srucface epithl cells and mucus neck clels

61
Q

what is main role of gip

A

slows down the digestion of fats to help maintain blood glucose level by reducing gastrin secretion

62
Q

role of somatatin

A

shud down acid secrtion by decrasing gasting, and histamine secreaion and inhibits pepsingoen section

63
Q

wher is somataisn secred form

A

d cells in stoahc

64
Q
A