Parkinson's

Question 1

therapeutic action Levodopa-Carbidopa

Answer 1

Parkinson’s disease

Question 2

mechanism of action Levodopa-Carbidopa

Answer 2

DOPA is a precursor for DA.
When levodopa is exogenously administered, it is comprehensively metabolised by the enzyme COMT.
In the peripheral nervous system Carbidopa blocks DC, which causes a larger amount of DOPA to cross the blood brain barrier.

Question 3

adverse effects Levodopa-Carbidopa

Answer 3

altered libido
hypotension
depression

Question 4

contraindications Levodopa-Carbidopa

Answer 4

endocrine disease

lactation

Question 5

drug interaction Levodopa-Carbidopa

Answer 5

Tryptophan