Epilepsy Flashcards
therapeutic action Barbiturates
epilepsy
mechanism of action Barbiturates
non-selective reduction of the CNS via an increase in neurotransmitters that use GABA receptors as a blocking system.
They can lower excitatory neurotransmitter results, which lowers the need for alertness and wakefulness > anaesthetic
adverse reactions Barbiturates
confusion
sedation
abnormal thinking
contraindications Barbiturates
elderly patients
debilitated patients
drug interaction Barbiturates
alcohol
therapeutic action Phenytoin
Seizures
mechanism of action Phenytoin
phenytoin inhibits voltage gated sodium channels, hereby reducing the multiplication of seizures.
adverse reactions Phenytoin
drowsiness
acne
blurred vision
contraindications Phenytoin
pregnancy
liver impairment
drug interaction Phenytoin
Warfarin
therapeutic action Gabapentin
neuropathic pain
mechanism of action Gabapentin
Gabapentin interferes with the calcium channels in the neurotransmitter, and hereby reduces the discharge of miscellaneous transmitters.
adverse reactions Gabapentin
tremor
nausea
anxiety
contraindications Gabapentin
renal impairment
haemodialysis > dialyse
drug interaction Gabapentin
morphine
therapeutic action Sodium Valproate
Bipolar
mechanism of action Sodium Valproate
possible impairment of K+, Ca2+ and N+ channels and GABA reuptake
adverse reactions Sodium Valproate
tremor
hair thinning
hepatoxicity
contraindications Sodium Valproate
liver disease
pregnancy
drug interaction Sodium Valproate
aspirin
