GIT Flashcards
Therapeutic Actions Antacids (magnesium hydroxide)
lowers stomach acid production
Mechanism of action Antacids (magnesium hydroxide)
neutralises hydrochloric acid levels in the stomach, causing a raise in stomach pH, thus protecting the duodenal lining and gastric epithelial cells
adverse reactions Antacids (magnesium hydroxide)
diarrhoea
chalky taste
belching
contraindications Antacids (magnesium hydroxide)
diarrhoea
Drug interaction Antacids (magnesium hydroxide)
hypoglycaemic drugs
Therapeutic Actions H2-antagonists
peptic ulcer disease
Mechanism of action H2-antagonists
decreases hydrochloric acid production and blocks the H2 receptor in parietal cells.
It helps to release pepsin from damaging the gastric mucosa, thus allows healing to occur.
adverse reactions H2-antagonists
dizziness
depression
can worsen joint-pain in pre-existing arthritis
contraindications H2-antagonists
caffeine
alcohol
Drug interaction H2-antagonists
Warfarin
Therapeutic Actions Proton Pump Inhibitors
GORD (gastro-oesophageal reflux disease)
Mechanism of action Proton Pump Inhibitors
prevents the proton pump to work properly in gastric parietal cells at the secretory surface.
it is irreversible and non-competitive, causing the mechanism of action to last for several days.
adverse reactions Proton Pump Inhibitors
dizziness
diarrhoea
abdominal pain
contraindications Proton Pump Inhibitors
impaired hepatic function
pregnancy
Drug interaction Proton Pump Inhibitors
Diazepam
