Diuretics

Question 1

therapeutic use Thiazide/Thiazide-like (indapamide)

Answer 1

hypertension

Question 2

Mechanism of action Thiazide/Thiazide-like (indapamide)

Answer 2

in the early distal tubules, the sodium-chloride symport in the luminal membrane is blocked by thiazide or thiazide-like drugs.
therefore, more sodium gets generated in the filtering that moves into the the collecting ducts and distal tubules.

Question 3

adverse effects Thiazide/Thiazide-like (indapamide)

Answer 3

dizziness
erectile dysfunction
decreased blood pressure

Question 4

contraindications Thiazide/Thiazide-like (indapamide)

Answer 4

severe renal impairment

hepatic disease

Question 5

drug interaction Thiazide/Thiazide-like (indapamide)

Answer 5

corticosteroids

Question 6

therapeutic use Loop (frusemide)

Answer 6

oedema

Question 7

Mechanism of action Loop (frusemide)

Answer 7

inhibition of the sodium-potassium-chloride transporter pump, the osmotic gradient in the loop of Henle is lost.

Question 8

adverse effects Loop (frusemide)

Answer 8

headaches
dizziness
constipation

Question 9

contraindications Loop (frusemide)

Answer 9

pregnancy

electrolyte disturbances

Question 10

drug interaction Loop (frusemide)

Answer 10

Lithium

Question 11

therapeutic use Potassium sparing (Spironolactone)

Answer 11

Liver cirrhosis

Question 12

Mechanism of action Potassium sparing (Spironolactone)

Answer 12

aldosterone antagonist

Question 13

adverse effects Potassium sparing (Spironolactone)

Answer 13

nausea
vomiting
gyneacomastia (breast growth in men)

Question 14

contraindications Potassium sparing (Spironolactone)

Answer 14

severe renal impairment

hyperkalaemia

Question 15

drug interaction Potassium sparing (Spironolactone)

Answer 15

ACE-1