anxiety Flashcards
1
Q
therapeutic actions Benzodiazepines (diazepam)
A
anxiety
2
Q
mechanism of action Benzodiazepines (diazepam)
A
the post-synaptic ligand-gated chloride channels get triggered by the inhibitory neurotransmitter GABA, which causes Cl- to enter the cell, hyperpolarisation of the cell membrane, neural cell reduction and thereby impairing the action potential.
GABA neurotransmission is impaired, resulting in anticonvulsant activity, sedation and relaxation.
3
Q
adverse effects Benzodiazepines (diazepam)
A
sedation
cognitive impairment
slurred speech
4
Q
contraindications Benzodiazepines (diazepam)
A
sleep apnoea
5
Q
drug interaction Benzodiazepines (diazepam)
A
St. John’s wort
