autonomic nervous system Flashcards
therapeutic action Adrenaline
emergency treatment anaphylactic shock
mechanism of action Adrenaline
both alpha- and beta-receptors are activated by adrenaline, but the main functions are the beta-receptors of the bronchi, blood vessels, heart and smooth muscle.
adverse effects Adrenaline
hyperactivity
arrhytmias
insomnia
contraindications Adrenaline
hypoxia (body is deprived of oxygen supply at the tissue level)
drug interaction Adrenaline
atherosclerosis
therapeutic action a1-selective antagonist (prazosin)
hypertension
mechanism of action a1-selective antagonist (prazosin)
selective barrier
decreased peripheral vascular resistance is caused by a selective barrier of post-synaptic a1-receptors, caused by impairment of vasoconstriction set in motion by catecholamine.
This causes a slight increase in heart rate
adverse effects a1-selective antagonist (prazosin)
dizziness
headache
fatigue
contraindications a1-selective antagonist (prazosin)
renal disease
liver disease
drug interaction a1-selective antagonist (prazosin)
beta-blockers
therapeutic action beta-blockers (propranolol)
hypertension
mechanism of action beta-blockers (propranolol)
catecholamine actions are competitively blocked due to the impairment of B-receptors.
It has both metabolic and cardiac effects
adverse effects beta-blockers (propranolol)
insomnia
fatigue
nightmares
contraindications beta-blockers (propranolol)
asthma
bradycardia
drug interaction beta-blockers (propranolol)
antacids