Depression

Question 1

therapeutic use Tricyclic antidepressants ((TCAs) Amitriptyline)

Answer 1

antidepressant (2nd line agent)

Question 2

mechanism of action Tricyclic antidepressants ((TCAs) Amitriptyline

Answer 2

hinders monoamine (5HT, noradrenaline) reuptake on the presynaptic terminal

Question 3

adverse effects Tricyclic antidepressants ((TCAs) Amitriptyline

Answer 3

nausea
blurred vision
dry mouth

Question 4

contraindications Tricyclic antidepressants ((TCAs) Amitriptyline

Answer 4

heart block

narrow angle glaucoma

Question 5

drug interaction Tricyclic antidepressants ((TCAs) Amitriptyline

Answer 5

Warfarin

Question 6

therapeutic use Serotonin Reuptake Inhibitors ((SSRI) Fluoxetine)

Answer 6

depression

Question 7

mechanism of action Serotonin Reuptake Inhibitors ((SSRI) Fluoxetine)

Answer 7

selective impairment of the 5-HT reuptake process, therefore extra amounts are obtainable to affect post-synaptic 5-HT receptors

Question 8

adverse effects Serotonin Reuptake Inhibitors ((SSRI) Fluoxetine)

Answer 8

nausea
sexual dysfunction
anorexia

Question 9

contraindications Serotonin Reuptake Inhibitors ((SSRI) Fluoxetine)

Answer 9

betablockers

anorexia

Question 10

drug interaction Serotonin Reuptake Inhibitors ((SSRI) Fluoxetine)

Answer 10

Warfarin

Question 11

therapeutic use Serotonin noradrenaline reuptake inhibitors ((SNRI) Venlafaxine)

Answer 11

anxiety

Question 12

mechanism of action Serotonin noradrenaline reuptake inhibitors ((SNRI) Venlafaxine)

Answer 12

impairment of norepinephrine and serotonin absorption in the brain

Question 13

adverse effects Serotonin noradrenaline reuptake inhibitors ((SNRI) Venlafaxine)

Answer 13

dizziness
insomnia
anorexia

Question 14

contraindications Serotonin noradrenaline reuptake inhibitors ((SNRI) Venlafaxine)

Answer 14

narrow angle glaucoma

hypersensitivity

Question 15

drug interaction Serotonin noradrenaline reuptake inhibitors ((SNRI) Venlafaxine)

Answer 15

Warfarin

Question 16

therapeutic use Reversible Monoamine Oxidase Inhibitors ((MAOI) Moclobemide)

Answer 16

antidepressant

Question 17

mechanism of action Reversible Monoamine Oxidase Inhibitors ((MAOI) Moclobemide)

Answer 17

non-selective and irriversible binding to monoamine oxidase-A and -B

Question 18

adverse effects Reversible Monoamine Oxidase Inhibitors ((MAOI) Moclobemide)

Answer 18

dry mouth
dizziness
insomnia

Question 19

contraindications Reversible Monoamine Oxidase Inhibitors ((MAOI) Moclobemide)

Answer 19

serotonin syndrome
tyramine effect (foods such as ages cheese, beer on tap etc.)

Question 20

drug interaction Reversible Monoamine Oxidase Inhibitors ((MAOI) Moclobemide)

Answer 20

Fluoxetine

Question 21

therapeutic use Atypicals (Mirtazipine)

Answer 21

antidepressant

Question 22

mechanism of action Atypicals (Mirtazipine)

Answer 22

Mirtazipine has an antagonist function at the presynaptic A2-receptor and the 5-HT2-receptor, causing an increase in norepinephrine and serotonin neurotransmission

Question 23

adverse reactions Atypicals (Mirtazipine)

Answer 23

sedation

weight gain

Question 24

contraindications Atypicals (Mirtazipine)

Answer 24

closed angle glaucoma

angina

Question 25

drug interaction Atypicals (Mirtazipine)

Answer 25

Diazepam