antifungals

Question 1

therapeutic action Azole antifungals

Answer 1

Candida

Question 2

mechanism of action Azole antifungals

Answer 2

Disturbs CP450 enzyme, due to its impact on the biosynthesis of fungal ergosterols. Causing cell leakage and death.

Question 3

adverse effects Azole antifungals

Answer 3

Drowsiness
vomiting
photophobia

Question 4

contraindications Azole antifungals

Answer 4

enzyme inducers

alcoholism

Question 5

drug interaction Azole antifungals

Answer 5

Warfarin

Question 6

therapeutic action Caspofungin

Answer 6

Invasive thrush

Question 7

mechanism of action Caspofungin

Answer 7

Prevents the composition of a glucose polymer, what is a necessary component for the structure of fungal cell walls

Question 8

adverse effects Caspofungin

Answer 8

vomiting
rash
flushing

Question 9

contraindications Caspofungin

Answer 9

liver disease

hepatoxicity

Question 10

drug interaction Caspofungin

Answer 10

cannabidiol

Question 11

therapeutic action Amphotericin B

Answer 11

candidiasis

Question 12

mechanism of action Amphotericin B

Answer 12

the cell permeability changes due to its binding in the fungal cell membrane to ergosterol, leading to loss of cell elements

Question 13

adverse effects Amphotericin B

Answer 13

GIT-distress
headache
hypokalaemia

Question 14

contraindication Amphotericin B

Answer 14

breastfeeding

leukocyte transfusion

Question 15

drug interaction Amphotericin B

Answer 15

prednisone