antibiotics

Question 1

Therapeutic use Penicillin

Answer 1

ear infection

Question 2

mechanism of action Penicillin

Answer 2

weakens cell wall through obstruction of transpeptidase enzimes, causing cell death and cell lysis.
permanently blocks transpeptidase active site

Question 3

adverse effects Penicillin

Answer 3

headache
diarrhoea
nausea
GIT distress
candida
allergies

Question 4

contraindications Penicillins

Answer 4

anaphylactic reactions

penicillin resistance

Question 5

drug interaction Penicillin

Answer 5

Warfarin

Question 6

Therapeutic use Erythromycin

Answer 6

respiratory tract infection

Question 7

mechanism of action Erythromycin

Answer 7

50S-ribosomal subunit binding to protein synthesis impairs bacterial RNA

Question 8

adverse effects Erythromycin

Answer 8

Headache
nausea
vomiting 
diarrhoea
dizziness
GIT-distress
thrush
hearing loss

Question 9

contraindications Erythromycin

Answer 9

allergic reaction

co-administration of Astemizole

Question 10

drug interaction Erythromycin

Answer 10

Warfarin

Question 11

mechanism of action Tetracycline

Answer 11

Inhibition of access of T-RNA to M-RNA ribosome complex & through reversible obstruction of 30S subunit, protein synthesis is impaired

Question 12

adverse effects Tetracycline

Answer 12

discolouration of teeth in children under 8

Question 13

drug interaction Tetracycline

Answer 13

Oral Contraceptives

Question 14

therapeutic use Tetracycline

Answer 14

skin infections

Question 15

contraindications Tetracycline

Answer 15

pregnancy

renal impairment

Question 16

Therapeutic use Ciprofloxacin

Answer 16

pneumonia

Question 17

mechanism of action Ciprofloxacin

Answer 17

Bactericidal

Question 18

adverse effects Ciprofloxacin

Answer 18

dizziness
drowsiness
photosensitivity

Question 19

contraindications Ciprofloxacin

Answer 19

alternative drugs

Question 20

drug interaction Ciprofloxacin

Answer 20

Warfarin

Question 21

therapeutic use Co-Trimoxazole

Answer 21

nose infection

Question 22

mechanism of action Co-Trimoxazole

Answer 22

Comparable in structure to PABA.
Trimethoprim inhibits synthesis of dihydropholic acid via dihydropholate reductase into tetrahydropholic acid, which enablesbacteria to synthesize purines into thymidine.

Question 23

adverse effects Co-Trimoxazole

Answer 23

photo-toxicity
sore mouth
seizure

Question 24

contraindications Co-Trimoxazole

Answer 24

renal-impairment

HIV

Question 25

drug interaction Co-Trimoxazole

Answer 25

Warfarin