Angiotensin II-antagonist (Losartan)

Question 1

therapeutic use Losartan

Answer 1

hypertension

Question 2

mechanism of action Losartan

Answer 2

prevents the binding of angiotensin II AT1-receptor to angiotensin II.
hereby decreasing plasma volume, increasing fluid and salt excretion, and relaxing smooth muscle

Question 3

adverse effects Losartan

Answer 3

renal impairment
vomiting
rash

Question 4

contraindications Losartan

Answer 4

hypersensitivity

pregnancy

Question 5

drug interaction Losartan

Answer 5

Indomethacin