lipid lowerihg drugs

Question 1

therapeutic action Statins (HMG-CoA reductase inhibitors)

Answer 1

Hyperlipidemia (lowers LDL-cholesterol)

Question 2

mechanism of action Statins (HMG-CoA reductase inhibitors)

Answer 2

Statins block the endogenous synthesis of cholesterol, which causes the liver cells to upregulate its LDL-receptors

Question 3

adverse effects Statins (HMG-CoA reductase inhibitors)

Answer 3

GIT-distress
myopathy (muscle disease)
liver failure

Question 4

contraindications Statins (HMG-CoA reductase inhibitors)

Answer 4

liver impairment

women of child bearing age

Question 5

drug interaction Statins (HMG-CoA reductase inhibitors)

Answer 5

antibiotics

Question 6

therapeutic action Fibrates

Answer 6

Hypertriglyceridemia (lowers cholesterol)

Question 7

mechanism of action Fibrates

Answer 7

Peroxisome proliferated-activated receptors (PPARs) are set in motion upon binding to antihyperlipidemic drugs or their natural ligands.
Fibrates help produce more HDL-cholesterol by increasing the formulation of apo A II and apo A I.

Question 8

adverse effects Fibrates

Answer 8

increases risk of developing cholelithiasis

increases risk of developing risk of malignancy development

Question 9

contraindications Fibrates

Answer 9

gallstones/gall bladder disease

liver disease

Question 10

drug interaction Fibrates

Answer 10

Warfarin

Question 11

therapeutic action Bile acid sequestrants (Cholestyramine)

Answer 11

Hypertryglyceridemia (lowers cholesterol)

Question 12

mechanism of action Bile acid sequestrants (Cholestyramine)

Answer 12

Cholestyramine causes negatively charged bile salts and bile acids to bind to anion-exchange resins in the small intestine.

Question 13

adverse effects Bile acid sequestrants (Cholestyramine)

Answer 13

constipation
nausea
vomiting

Question 14

contraindications Bile acid sequestrants (Cholestyramine)

Answer 14

gallstones

hypothyroidism

Question 15

drug interaction Bile acid sequestrants (Cholestyramine)

Answer 15

Warfarin

Question 16

therapeutic action Nicotinic Acid (Niacin)

Answer 16

Increases plasma HDL concentrations

Question 17

mechanism of action Nicotinic Acid (Niacin)

Answer 17

stops fatty acids release;

triglycerides can’t be onverted into fatty acids, thus lowering the blood cholesterol

Question 18

adverse effects Nicotinic Acid (Niacin)

Answer 18

nausea
abdominal pain
intense cutaneous flush

Question 19

contraindications Nicotinic Acid (Niacin)

Answer 19

gout

hepatic disease

Question 20

drug interaction Nicotinic Acid (Niacin)

Answer 20

Simvastatin