Obesity Drug Therapy (Exam 2)

Question 1

Drug Therapy for Obesity

Answer 1

Orlistat (Xenical/alli)

Question 2

Orlistat: MOA

Answer 2

-OTC medication

-Binds to gastric and pancreatic enzymes and BLOCKS these enzymes; reduces fat absorption by 30%

Question 3

Orlistat: Side Effects

Answer 3

-Black Box: Liver injury

-GI: Oily spotting, flatulence, and fecal incontinecne

-Decrease vitamin concentration (Must take with multi vitamin)

Question 4

Teaching Point:

Answer 4

Must take for 3 months to start seeing effect

Question 5

Drug Therapy Considerations

Answer 5

-Must use with Diet and Exercise

-Best for people with high health risk. (BMI greater than 30) (BMI greater than 27 with risk factors)

-Most doctors will nto prescribe unless patients have tried diet and exercise alone for 6 months

-Limited effectiveness

-Long term treatment (REBOUND)

Question 6

Other treatment options for Obesity

Answer 6

Bariatric sugery: Liposuction-Gastric Bypass-Grastric Banding

Question 7

Metabolic Syndrome

Answer 7

-Grouping of risk factors who put someone at risk for CVA and CVD

-Must have 3 factors

Waist Circumference: Men > 40. Women > 35

Triglycerides: > 150mg/dL or drug treatment

HDL cholesterol: <40 mg/dL men. < 50 mg/dL in women

BP: >130 systolic or >85 diastolic

FBG: >110 mg/dL

DRUG TREATMENT CAN SUBSITUTE

Question 8

What do we do for metabolic syndrome

Answer 8

-Treat the condition individually

Most important: TEACH

Question 9

What can make loosing weight even more difficult

Answer 9

Our social determinants of health