Depression and Anxiety (Final) Flashcards

1
Q

Neurotransmitters

A

-Chemicals that enable neurotransmission

-Travels across the synapse and either blocks or facilitate relay of stimulus

-Problems that arise with neurotransmitters are associated with neurologic and psychiatric disorders

-Over 200 neuortransmitters

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2
Q

4 Major Neurotransmitters

A

Dopamine

Norepinephrine

Serotonin (5HT)

GABA

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3
Q

What is dopamine responsible for?

A

Attention
Motivation
Pleasure
Reward

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4
Q

What is serotonin responsible for?

A

Obsessions and compulsions

Happiness and sleep

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5
Q

What is norepinephrine responsible for?

A

Alertness and energry

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6
Q

Which neurotransmitters are responsible for mood and anxiety?

A

Dopamine and Serotonin

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7
Q

What is GABA responsible for?

A

Relaxation

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8
Q
A
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9
Q

Serotonin Deficit

A

Depression and Craving

-Obsessive thoughts
-Compulsive behavior

Increase Impulsivity
-Suicide
-Agression
-Cue Triggers

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10
Q

Dopamine Deficit

A

Depression and Craving

-Parkinson-Like Symptoms
-Slow reaction
-Anergia (LOE)

-AMNEDONIA (Inability to experience pleasure)
-Pleasure center
-Dysfunction

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11
Q

GABA

A

-Principle inhibitory neurotransmitter

-GABA dysfunction is associated with anxiety disorders (Panic)

-Recently been connected to major depressive disorder

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12
Q

Noerpinephrine

A

-Excitatory neurotransmitter associated with fight or flight response

-High levels associated with: anxiety, stress, hyperactivity

-Low levels associated with: Lack of energy, focus, and motivation

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13
Q

Depression: More common

A

-In women
-White
-Those never been married

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13
Q

Those with depression have greater risk of developing

A

CAD

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14
Q

Depression: Eitology

A

-Is caused by a complication of genetic, biological, environmental and psychosocial factors

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15
Q

Diagnosis of depression requires the presences of multiple symptoms that are intense enough to cause distress and to

A

Persistently impair psychosocial functioning

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15
Q

Depressive Symptoms

A

-Loss of interest or pleasure

-Fatigue

-Restlessness and irritabile

-Impaired concentration

-Low self-esteem

-Negative thinking

-Sleep disturbances

-Appetite disturbances

16
Q

Depression Treatment

A

-Medications (most important thing is telling patients that i takes WEEKS for these medications to start working, so keep with it

-Psychotherapy-Talk therapy

-Psychoeduction and support groups

-Brain stimulation therapy

-Works best when all of these are combined together in some way that best fits the patients needs

17
Q

Anxiety: Panic Disorder two important psychological symptoms

A

Anticipatory anxiety: Fearful expectation of panic anxiety onset

Avoidance anxiety: Personal strategies used to increase feeling of control and decrease the risk of panic anxiety

18
Q

Panic Disorder: Etiology

A

-Biopsychological and Physiologic

Genetics and family history

Early childhood stress linked to adult onset anxiety disorderd

19
Q

Overwhelming stress can induce circulation stress hormones which stimulates

20
Q

What is panic?

A

-Unexpected episodes of reactions that are out of proportion to events going on around patient

-Many (50%) of patients with panic also have depression

-Creates a terrible cycle of panic attacks and anxiety

21
Q

Panic attacks: What are they and what are the symptoms?

A

Recurrent uncomfortable episodes with sudden onset with symptoms

-Heart palpitations
-Chest pain
-SOA
-Dizziness
-Nausea
-Fear of Losing control

22
Q

Treatment of Panic Disorders

A

-Cognitive Behavioral Therapy

-Anti-dpressants
-SSRI
-SNRI
-TCA
-MAO inhibitors

Benxodiapzepines (Second line)

23
Generalized Anxiety Disorder
-Chronic condition -More than 6 months -Excessive, uncontrolled, unrealistic worry. Going down a rabbit hole
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GAD symptoms
-Accompanied by muscle tension, autonomic hyperactivity, exaggerated startle, difficulty concentrating
25
Risk factors for GAD
-Use of certain substances -Childhood abuse or family trauma -Genetics
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GAD Treatment
-Cognitive Behavorial Therapy -SSRI and SRNI -Buspirone = unknown MOA, no sedation/abuse, does not intensify the effects of CNA depressants, anxiolytic effects slow -Benzodiazepines
27
Post-Traumatic Stress Disorder: 3 core symptoms
-Hyper-arousal -Avoidance of reminders -Re-experiencing the events
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Post-Traumatic Stress Disorder: Characterized
By vivid flashbacks, nightmares, emotional blunting, irritability and exaggerated startle Memory, sleep and depression problems very common in PTSD
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PTSD: Treatment
Psychotherapy-Trauma focused, exposure therapy, CBT EMDR - Eye movement desensitization and reprocessing Medications SSRI and SNRI
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Social Anxiety Disorder
-Intense fear of being criticized by others -Persistent fear of humiliation -Negative evaluation of embarrassment in social situations -Withdraw from situations or experience intense discomfort
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SAD: Causes
-Inherited traits -Brain structure: amygdala plays role in the fear response -Environment: May be a learned behavior
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Treatment of SAD
CBT SSRI BENZO Propanolol- 1 to 2 hours before activity
33
Obsessive Compulsive Disorder
Obsession: Repetitive unwanted thoughts Compulsions: Repeated activités / rituals Time consuming: May be distressing to individual, friends, family members
34
OCD Treatment
VERY VERY difficult to treat -SSRI -TCA (second line) -Deep brain stimulation -EMDR -Transcranial Magnetic Stimulation: FDA approaved
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SSRI and SNRI
Used first line because they are the most safe medicaitons
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All anti depressant medications come with the risk of
Suicide and mental imbalance because they affecting the neurotransmitter
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After starting drug should be monitor for 4-8 weeks for efficacy
Can increase dose Switch drug or drug class Add second drug
38