CBC (Exam 3) Flashcards
Red Blood Cells
Erythrocytes
most abundant cells of the blood
Erythrocytes: Different in males and females
Males about 48%
Females about 42%
Normal Total Count Eryhtrocytes
4.2-4.6 million erythrocytes/mm3
Primary responsibility of Erythrocytes
Tissue oxygenation
Hemoglobin carries these gasses –> why we measure hemoglobin
White Blood Cells: Leukocytes
Never
Let
Monkey
Eat
Bananas
Neutrophils
Lymphocytes
Monocoytes
Eosinophiles
Basophils
White blood cells: Leukocytes categories
- Granulocytes:
-Neutrophils (50-67%)
-Eosinophiles (0-3%)
-Basophiles (0-2%)
1.Argranulocytes
-Lymphocytes (24-40%)
-Monocytes (4-9%)
Granulocytes
Cells with nucleus, several lobes and granules.
Granules release mediators with inflammatory and immunity properites
Agranulocytes
Participates in immune response but do not release immune mediators
Neutrophiles
-First to arrive at site of inflammation
-Bands and segs (Band immature) (Seg mature)
-Increase with acute bacterial infections and trauma
-Shift to the left (increase of bands) (Acute stage of bacterial infection)
Lymphocytes
-Primary cells of immune response
-T-cells and B-cells
-Increase with chronic bacterial infection and acute viral infection
Acute bacterial infections
Strep throat or something that is resolved quickly
Chronic Bacterial Infection
Wound on foot with MRSA. Last for long time
Monocytes
-Phagocytosis cells (eat left over junk)
-Increase with bacterial infections and cancers
Eosinophils
-Role in phagocytosis
-Increase with allergic reactions or parasitic infections
-Worms; wheezes and weird disease
Basophiles
-Increase with allergic reactions (Hypersenitivies, inflammatory reactions)
Argangular Leukocytes
-Lymphocytes
-Monocytes
Granular Leukocytes
Basophils
Neutrophils
Eosinophils
Hemoglobin (Hgb)
-Measure amount of hemoglobin in your blood (oxygen carrying capacity)
Hgb Normal Values
Male: 14-18
Female: 12-16
Low Hemoglobin
Bleeding, folate/B12 deficiencies, cancers, kidney and liver disease
High hemoglobin
Polycythemia, COPD, live in high altitude and heavy smokers
Hematocrit (Hct)
-Percentage of blood that is made up of packed red blood cells
Hematocrit: Interpreted in percentages
A Hct of 40% indicates that there are 40 mL of packed RBC’s in 100 ml of blood
Low Hematocrit
Anemia, bleeding, bleeding disorder, and fluid imbalances
high hematocrit
polycythemia, COPD, dehydration, shock, congenital heart disease
Other Red Cell Labs
Red cell count: total # of erythrocytes in the blood
Mean corpuscle volume: Size of erythrocytes
Mean corpuscle hemoglobin (MCH): Amount of hemoglobin in erythrocyte by weight
WBC total count
5,000 - 10,000
Increase WBC
Leukocytosis
Decreased WBC
Leukopenia
Decreased neutrophiles
neutropenia
CBC
Complete Blood Count
WBC
Platelet
RBC
Hct
Hgb
WBC with Diff (CBC with DIff)
-2 componenets
- Total number of WBC’s in mm3 (absolute number)
- Determination of the proportion of each of the 5 WBC’s in a sample of 100
CBC with DIff Interpretation
-An increased % in one type means a decrease in % of another type
-Although the absolute # of the second type does not change
Example PP
Reading CBC
What else to look for with an infection:
-Increased in temperature
-Fever can improve immune response
-Decrease virulence of some bacteria
Leukopenia: Neutropneia
-Most often cancer patients
-Susceptible to bacterial infections
Neutropenia: Precautions
-Good hygiene
-Avoid contact with people who are sick
-Avoid raw fruits, vegetables, grains
-No fresh flowers
-Keep door closed
Leukopenia: Pharmacologic treatment
-Hematopoietic agents
Filgrastim: Class
Granulocyte Colony stimulating factors
Filgrastim: MOA
Promoting proliferation, differentiation, activation of cells that make granulocytes
Filgrastim: Indications
Malignancies, chemo-induced leukopenia, bone marrow transplant, harvesting of hematopoietic stem cells, chronic neutropenia
IV or Sub Q
Filgrastim: Adverse Effect
Bone pain, leukocytosis
Pegfilgrastim:
MOA
Route
AE
Long acting derivative of filgrastim
Increased production of neutrophils
-SQ
-Bone Pain
Pegylated = delayed excretion by the kidneys