NSAIDs

Question 1

Reye Syndrome

Answer 1

acute noninflammatory encephalopathy and fatty liver degeneration

Question 2

_______ drug is used to treat osteoporosis

Answer 2

biphosphonates

Question 3

Reye Syndrome is associated with the use of __ drug

Answer 3

associated with the use of aspirin during viral infections, particularly influenza and chickenpox.

Question 4

• Aspirin (ASA)

Answer 4

Nonselective inhibitor of COX, irreversible inhibitor (all other NSAIDs are reversible/competitive inhibitors)

Question 5

Distribution of aspirin

Answer 5

bound to plasma albumin

Question 6

Salicylism

Answer 6

ASA toxicity
tinnitus, sweating, headache, and dizziness

Question 7

DI of aspirin

Answer 7

§ Anticoagulants: warfarin, heparin, and others
§ Glucocorticoids: GI ulcer
§ Alcohol: GI bleed
§ Non-aspirin NSAIDs- reduce antiplatelet effects of aspirin
§ ACE inhibitors and ARBs- impair renal function
§ Vaccines: blunt immune response to vaccines

Question 8

Ibuprofen can cause ____ syndrome

Answer 8

○ Steven-Johnson Syndrome

Question 9

Celecoxib

Answer 9

2nd generation NSAIDs only inhibit COX 2

Question 10

COX 1 is ___, COX 2 is

Answer 10

COX 1 is good, COX 2 is bad

Question 11

_____ can cause Sulfonamide allergy

Answer 11

celecoxib Sulfonamide allergy

Question 12

acetaminophen MOA

Answer 12

selective inhibition of COX in CNS, reduce fever and pain

Question 13

Antidote for actemainophen overdose

Answer 13

acetylcysteine (PO or IV)