glucocorticoids

Question 1

Physiological effects of gucocorticoids on metabolism

Answer 1

• Metabolism:
  ○ Elevation of blood glucose
  ○ Suppress synthesis of proteins
  ○ Stimulation of lipolysis

Question 1

Physiological effects of gucocorticoids on Cardiovascular and Hematologic Systems

Answer 1

○ Increase RBC and neutrophile
○ Decrease lymphocytes, eosinophils, basophils and monocytes

Question 2

glucocorticoids on CNS

Answer 2

neural excitability

Question 3

glucocorticoids on Stress response

Answer 3

maintain BP and blood glucose level

Question 4

glucocorticoids on Fluids and electrolytes

Answer 4

promote retention of sodium and water, promote excretion of potassium

Question 5

glucocorticoids on Neonatal Respiratory system

Answer 5

hasten maturation of the lungs

Question 6

Control of Glucocorticoid Synthesis and Secretion

Answer 6

negative feedback system

Question 7

Glucocorticoid receptors are located _____ the cell rather than ____

Answer 7

Glucocorticoid receptors are located inside the cell rather than on cell surface

Question 8

Glucocorticoids modulate the ______ rather than ______

Answer 8

Glucocorticoids modulate the production of regulatory proteins rather than the activity of signaling pathways

Question 9

Side Effects of glucocorticoids

Answer 9

• Osteoporosis (systemic glucocortioid therapy)
  
  • Infection
  • Impaired Wound healing
  • Hyperglycemia
  • Myopathy
  • Fluid and electrolyte disturbance
  • Growth delay
  • Psychologic Disturbances: insomnia, anxiety
  • Cataracts and glaucoma
  • Peptic Ulcer Disease
  • Iatrogenic Cushing Syndrome
  • Adrenal Suppression (over 3 weeks)

Question 10

DI of glucocorticoids

Answer 10

• Potassium loss
  
  • NSAIDs: increase risk of GI bleed
  • Insulin and oral hypoglycemic
  • Vaccine: immunosuppressant action of glucocorticoids
  • Contraindicated for patients with systemic fungal infection and those receiving live virus vaccines.