Innate Immunity Flashcards

1
Q

First line of Defence include

A

Physical and Biochemical Barriers and the Human Microbiome

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2
Q

Epithelial Cell-Derived Chemicals
Antimicrobial peptides

A

cathelicidins
Defensins
Collectins

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3
Q

GI bacteria flora functions

A

a) Produce enzymes that facilitate the digestion and utilization of many molecules in the human diet
b) Usable metabolites
Antibacterial factors that prevent colonization by pathogenic microorganisms

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4
Q

Second line Defence

A

Inflammation

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5
Q

4 characteristics of inflammation

A

a) Occurs in tissues with a blood supply (vascularized)
b) Rapid activation
c) Depends on cellular and chemical components
d) Nonspecific

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6
Q

Inflammation process (3 steps)

A
  1. Vasodilation
  2. Increased vascular permeability
  3. White blood cell adherence
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7
Q

4 Benefits of inflammation

A

§ Prevents infection and further damage by microorganisms
§ Limits and controls the inflammatory process
§ Interacts with components of the adaptive immune system to elicit a more-specific response to contaminating pathogens
§ Prepares the area of injury for healing and repair

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8
Q

Complement system

A

a) Activation of C3 and C5

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9
Q

3 major pathways control the activation of complement system inflammation

A

a) Classic pathway: activated by antibodies
b) Alternative pathway: activated by substances on the surface of bacteria
c) Lectin pathway: activated by plasma proteins that recognize carbohydrate patterns of pathogens

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10
Q

Classic pathway activated by

A

activated by antibodies

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11
Q

Alternative pathway activated by

A

activated by substances on the surface of bacteria

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12
Q

Lectin pathway activated by

A

activated by plasma proteins that recognize carbohydrate patterns of pathogens

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13
Q

Four functions of inflammation

A

a) Opsonization
b) Anaphylatoxic activity, mast cell degranulation
c) Leukocyte chemotaxis
d) Cell lysis (MAC)

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14
Q

3 functions Clotting system

A

a) Stop bleeding
b) Trap microorganisms
c) Provide framework for future repair

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15
Q

Kinin system

A

Prekallikrein–> bradyknine –>
· vessel dilation,
· prostgalndins (pain)
· Increase vascular permeability
Control and Interaction of Plasma Protein system

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16
Q

Mast cells

A

activation of inflammation

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17
Q

Dendritic cells

A

connect innate and acquired immune responses

18
Q

Cellular Receptors types

A

§ Pattern recognition receptors (PRRs)
§ Toll-like receptors (TLRs)
§ Complement receptors
§ Scavenger receptors
§ NOD-like receptors (NLRs)

19
Q

Cytokines

A

intercellular -signalling molecules
§ Pro or anti- inflammatory

20
Q

§ Cytokine storm syndrome

A

over active immune response

21
Q

degranulation release ___

A

histamine

22
Q

Histamine to H1 is

A

pro-inflammatory

23
Q

Histamine to H2 is

A

anti-inflammatory

24
Q

Chemotaxis

A

directional movement of cells along a chemical gradient created by a chemotactic factor

25
Q

Leukotrines

A

increase vascular permeability

26
Q

Prostagladins

A

pain

27
Q

Prostacyclin

A

increase blood flow

28
Q

Diapedesis

A

emigration of the cells through the junctions

29
Q

5 steps of phagocytosis

A
  1. Recognition and adherence of the phagocyte to its target
    2. Engulfment
    3. Formation of a phagosome
    4. Fusion of the phagosome with lysosomal granules within the phagocyte
    5. Destruction of the target
30
Q

Oxygen-dependent killing mechanisms

A

production of toxic oxygen species;

31
Q

Oxygen-independent mechanisms:

A

a) Acidic pH (3.5-4) of the phagolysosome
b) Cationic proteins
c) Enzymatic attach by lysozyme and other enzymes
d) Inhibition of bacterial growth by lactoferrin binding of iron

32
Q

Local Manifestations of Acute Inflammation

A

§ Serous exudate
§ Fibrinous exudate
§ Purulent exudate
§ Hemorrhagic exudate

33
Q

Systemic Manifestations of Acute Inflammation

A
  1. Fever
    a) Endogenous pyrogens
  2. Leukocytosis
  3. Increased circulating plasma proteins
    a) ESR- indication of acute inflammatory response
    b) C-reactive protein
34
Q

Chronic Inflammation

A

§ Last more than 2 weeks
§ Macrophages differentiate into
□ Epithelioid cells
□ giant cells

35
Q

Wound Healing 3 phases

A

Phase 1: inflammation
Phase 2: proliferation and New tissue formation (day 3-4 ~ 2 weeks)
Phase 3: remodelling and maturation

36
Q

Dysfunctional Wound Healing

A
  1. Ischemia
  2. Excessive bleeding
  3. Obesity
  4. Excessive fibrin deposition
  5. A predisposing disorder, e,g DM
  6. Wound infection
  7. Inadequate nutrients
  8. Numerous medications
  9. Tabacco smoke
37
Q

3 plasma protein systems provide a biochemical barrier against invading pathogens in the circulation

A

complement system,
clotting system
kinin system

38
Q

Local manifestations of inflammation include

A

vasodilation and increased capillary permeability

39
Q

3 primary systemic effects of inflammation

A

fever, leukocytosis, and an increase in the levels of circulating plasma proteins

40
Q

Resolution and repair occur in two separate phases

A

reconstructive phase: the wound begins to heal
maturation phase: the healed wound is remodeled