Adaptive Immunity Flashcards

1
Q

4 characteristics of adaptive immunity

A
  1. Inducible
  2. Specific
  3. Long-lived and systemic
  4. Memory
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2
Q

Clonal diversity

A

large population of B and T cells before birth capable of recognizing different antigens

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3
Q

Humoral immunity

A

antibodies circulate in the blood

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4
Q

Clonal selection

A

infection occurs, B cells develop into plasma cells; T cells develop into (Thelper, Tcytotoxic, Tregulatory)

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5
Q

Cellular immunity

A

T cells in the blood and tissues defend against intracellular pathogens

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6
Q

Active immunity

A

individuals develops antibodies to antigens; long-lived

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7
Q

Acquired immunity

A

maternal antibodies pass through placenta to newborn; short-lived

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8
Q

Haptens

A

too small to be immunogens, but can combine with larger molecules (carriers for hapten)

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9
Q

5 Classes of Immunoglobulins

A

i. IgG: most abundant, cross placenta
ii. IgA: in blood and bodily secretions
iii. IgM: largest
iv. IgE: low concentration; allergy and parasite
v. IgD: low concentration, antigen receptor on early B cells

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10
Q

Fabs (Antigen-binding fragments)

A

receptor site

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11
Q

Fc (crystallizable fragment)

A

biological function of antibodies

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12
Q

Light chain contains

A

variable region- Complementarity Determining Regions (CDRs)- specificity of antibodies to antigen

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13
Q

Heavy chain contains

A

constant region

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14
Q

Epitope

A

(on antigen): antigenic determinant

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15
Q

Functions of Antibodies (direct and indirect mechanisms)

A

§ Direct mechanism:
§ Neutralization
§ Agglutination
§ Precipitation
§ Indirect mechanism:
§ Fc portion activate components of the innate immune response, complement and phagocytes

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16
Q

Paratope

A

(on antibody): antigen-binding site

17
Q

BCR
TCR

A

B cell antigen receptor
T cell antigen receptors

18
Q

Somatic recombination

A

rearrangement of existing DNA during C-cell development in the primary lymphoid organs

19
Q

Central tolerance

A

immunocompetent B cells that initiate a response against foreign antigens and are tolerant to self-antigens

20
Q

All T cells can be identified by__ on their surface

A

CD3

21
Q

APCs - antigen presenting cells

A

dendritic cells, macrophages

22
Q

Primary immune response

A

5-7 days, IgM

23
Q

Secondary immune response

A

rapid production of a larger amount of antibody than the primary response; more IgG

24
Q

MHC 1

A

all nucleated cells: endogenous, recognized by Tc

25
Q

MHC 2

A

on APCs (macrophages, dendritic cells, B cells)

26
Q

3 complementary intracellular signalling events

A

i) Antigen-specific recognition through the TCR complex
ii) Activation of intercellular adhesion molecules
iii) The response to specific groups of cytokines

27
Q

Class switch in B cell maturation

A

change in antibody production from one class to another (e.g. IgM to IgG)

28
Q

Natural killer (NK) cells

A

lack antigen-specific receptors, has MMHC 1 receptor, but no CD8

29
Q

Treg cells ___immune response

A

Treg cells limit immune response

30
Q

___ (antibodies )from placenta for first 6 months

A

IgG

31
Q

(6) Factors influence the capacity of a pathogen to cause disease

A

§ Communicability
§ Portal of entry
§ Infectivity
§ Virulence
§ Pathogenicity
§ Toxigenicity

32
Q

Countermeasures Against Infectious Microorganisms
(4 ways)

A

○ Infection Control Measure
○ Antimicrobials
○ Active Immunization
○ Passive Immunity

33
Q

4 types of Hypersensitivity

A
  1. Type I: IgE mediated Reactions
  2. Type II: tissue specific reactions
  3. Type III: immune complex-mediated reactions
  4. IV: cell mediated reactions
34
Q

5 classes of antiretroviral drugs

A
  • Reverse transcriptase inhibitor
    • Integrase strand transfer inhibitors (INSTIs)
    • Protease inhibitors (PIs)
    • Fusion inhibitors
    • CCR5 antagonists