Neurodegenerative Disease Flashcards
Levodopa
Parkinsons
Levodopa MOA
metabolic precursor to Dopamine. Becomes dopamaine to restore post-synaptic concentration of dopamine. Activates post-synaptic D1 and D2 receptors
Carbidopa
inhibits dopa decarboxylase to allow levodopa to enter the BBB
Levodopa contraindications
MAOI use, history of malignant melanoma, narrow angle glaucoma. Monitor LFT
Levodopa ADR
Dyskinesias, “on-off” effect, Nausea, anorexia, hypotension, confusion, insomnia, nightmares, schizophrenic like syndrome
Dopamine Agonists
apomorphine, bromocriptine, pergolide, pramipexole, ropinirole, rotigotine
Dopamine Agonists ADR
N/V, anorexia, hypotension, cardiac arrythmias, HA, confusion, hallucinations, sedation, pulmonary fibrosis
Ergot Dopamine Agonists
Bromocriptine and Cabergoline. D2 receptor agonists
NonErgot Dopamine Agonists
Pramipexole, Ropinerole, Rotigotine (patch), Apomorphine
Pramipexole indications
advanced Parkinsons and restless leg syndrome
Ropinerole indications
monotherapy in mild parkinsons and restless leg syndrome
Rotigone ADR
sudden somnolence
Apomorphine receptor type
D1/D2
Pramipexole receptor type
D3. some D2/D4
Ropinerole receptor
D2
Apomorphine indications
subQ injection for temporary relief of “off” periods
Apormorphine ADR
dyskinesias, drowsiness, sweating, hypotension
Selegiline MOA
monoamine oxidase- B inhibitors