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Neuro Drugs Flashcards

1
Q

Pyridostigmine

A

Myasthenia gravis. Acetycholinesterase inhibitor

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2
Q

Neostigmine

A

myasthenia gravis. Acetylcholinesterase inhibitor

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3
Q

Acetylcholinesterase inhibitor ADR

A

Cholinergic crisis, rash, NVD, adb cramps, increased salivation, increased bronchial secretions, muscle cramps, weakness

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4
Q

Riluzole

A

ALS

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5
Q

Riluzole ADR

A

NVD, asthenia, dizziness, decreased lung function, abd pain, pneumonia, vertigo, parasthesia, anorexia, somnolence

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6
Q

Tetrabenazine

A

Chorea

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7
Q

Tetrabenazine ADR

A

depression, fatigue, insomnia, dizziness, akathisia

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8
Q

Interferon Beta

A

Multiple sclerosis

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9
Q

Glatiramer acetate

A

MS.

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10
Q

Dimethyl fumurate

A

MS.

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11
Q

IVIg

A

MS.

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12
Q

Mitoxantrone

A

MS.

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13
Q

Natalizumab

A

MS.

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14
Q

Fingolimod

A

MS.

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15
Q

Teriflunomide

A

MS.

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16
Q

Dalfampridine

A

walking in MS.

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17
Q

Dantrolene

A

muscle relaxant for MS and malignant hyperthermia

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18
Q

Nuedexta

A

pseudobulbar affect in MS

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19
Q

Oral MS drugs

A

Dimethyl fumurate, Fingolimod, Teriflunomide, dalfampridine

20
Q

Injectable MS

A

Interferon beta, IVIg, Mitoxantrone, Natalizumab, dantrolene, neudexta

21
Q

interferon beta MOA

A

immunomodulator, anitviral, antiproliferative

22
Q

Interferon beta warnings

A

depression, suicide, psychotic disorders, hepatoxicity, new autoimmune disorders, CHF, blood dyscrasias, seizures

23
Q

interferon beta ADR

A

flu like symptoms, insomnia, injxn site reaction, peripheral edema, malaise, HTN, incoordination

24
Q

Glatiramer acetate MOA

A

immunomodulator

25
Q

Glatiramer acetate warnings

A

post injection reaction- flushing, chest tightness, palpitations, dyspnea, throat constriction

26
Q

Glatiramer acetate ADR

A

vasodilation, rash, dyspnea, chest pain, anxiety, diaphoresis, nausea, pain, weakness, infection

27
Q

Mitoxantrone MOA

A

antineoplastic, inhibits topoisomerase, T cells and B cells

28
Q

Mitoxantrone warnings

A

myelosuppression, cardiotoxicity, secondary AML

29
Q

Mitoxantrone ADR

A

nausea, alopecia, menstrual changes, URI, UTI, blue-green urine, preg cat D

30
Q

Natalizumab MOA

A

binds leukocytes and inhibits adhesion

31
Q

Natalizumab warnings

A

progressive multifocal leukoencephalopathy

32
Q

Dimethyl fumurate ADR

A

leukopenia, flushing, rash, NVD, abd pain, indigestion

33
Q

fingolimod MOa

A

keeps WBC inside lymph nodes so they don’t cross BBB into CNS

34
Q

Fingolimod ADR

A

first dose bradycardia, varicella zoster, increased mortality, PML, HA, flu, diarrhea, back pain, abnormal LFT, cough

35
Q

Teriflunomide MOA

A

pyrimidine synthesis inhibitor. inhibits immune cells

36
Q

Teriflunomide ADR

A

hepatoxic, teratogenic, bone marrow suppression, peripheral neuropathy, hyperkalemia, transient renal failure, ND, abnormal LFT, flu, alopecia

37
Q

Dalfampridine MOA

A

calcium channel blocker

38
Q

Dalfampridine contraindications

A

renal impairment and seizures

39
Q

Dantrolene contraindications

A

liver disease

40
Q

Dantrolene ADR

A

drowsiness, dizziness, malaise, diarrhea

41
Q

Neudexta MOA

A

dextramethorphan- NMDA receptor antagonist and quinidine increases bioavailability of dextramethorphan

42
Q

neudexta contraindications

A

long qt, AV block

43
Q

Neudexta ADR

A

NVD, cough, liver

44
Q

Pyridostigmine contraindications

A

urinary or bowel obstruction, Asthma/COPD

45
Q

Pyridostigmine ADR

A

cholinergic crisis, rash, NVD, cramps, peristalsis, salivation, bronchial secretions, diaphoresis, muscle cramps, fasiculation, weakness

Pharmacology (33 decks)

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