Cephalosporins

Question 1

MOA

Answer 1

inhibits bacteria cell wall synthesis

Question 2

Spectrum

Answer 2

Staph, Strep, pneumococcus, E. coli, K. pneumo, P. mirabilis

Question 3

1st generation

Answer 3

cephalexin, cefazoline, cefadroxil

Question 4

1st generation indications

Answer 4

GAS pharyngitis, impetigo, SSTI, UTI

Question 5

1st generation contraindications

Answer 5

PCN allergy

Question 6

1st generations ADR

Answer 6

NVD, pancytopenia, hepatitis, CDAD

Question 7

2nd generation

Answer 7

cefaclor, cefprozil, cefuroxime, ceftetan, cefoxitin, ceforoxime

Question 8

2 Spectrum

Answer 8

extended gram -

Question 9

2 indications

Answer 9

GAS pharyngitis, AOM, acute sinusitis, bronchitis, SSTI, UTI, early lyme, preop prophylaxis, bone/joint

Question 10

3rd generation

Answer 10

cefixime, ceftibuten, cefpodoxime, cefditoren, ceftazidime, ceftriaxone, cefotaxime

Question 11

3 spectrum

Answer 11

better gram -, some cross BBB, some active against pseudomonas

Question 12

3 ADR

Answer 12

can be seizures

Question 13

4th generation

Answer 13

cefepime

Question 14

4 spectrum

Answer 14

broad-pseudomonas, strep, enterobacter

Question 15

4th indications

Answer 15

pneumonia, febrile neutropenia, UTI, SSTI, peritonitis

Question 16

5th generation

Answer 16

ceftaroline

Question 17

5th indications

Answer 17

CAP, SSTI

Question 18

5th ADR

Answer 18

drug induced hemolytic anemia