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Pharmacology > Headache drugs > Flashcards

Headache drugs Flashcards

1
Q

Triptans

A

Sumatriptan, Solmitriptan, Rizatriptan, Naratriptan, Eletriptan, Almotriptan, Frovatriptan

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2
Q

Other Abortive agents

A

Dihydroergotamine, analgesics, NSAIDs, compound preparations, Narcotics

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3
Q

Caffeine

A

antagonizes adenosine receptors

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4
Q

Fiorinal

A

Butalbital, aspirin, caffeine

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5
Q

Fioricet

A

Butalbital, acetometaphin, caffeine

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6
Q

Fiorinal/Fioricet indications

A

tension headaches

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7
Q

Fiorinal/fioricet ADR

A

nausea, abdominal pain, drowsiness, dizziness

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8
Q

Triptan MOA

A

serotonin receptor agonists. 5-HT receptor found on cranial arteries, basilar artery, and dura mater vasculature. Mediates vasoconstriction

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9
Q

Triptan indications

A

acute migraine with or without aura

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10
Q

Triptan uses

A

moderate to severe migraine, mild to moderate migraine that doesn’t respond to NSAIDs

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11
Q

Triptan contraindications

A

basilar migraine, ischemic cardiac, cerebrovascular, or peripheral vascular syndromes, uncontrolled HTN, liver disease

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12
Q

Triptan ADR

A

coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia Vfib, HTN, parasthesias, fatigue, flushing, chest tightness, sweating

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13
Q

Ergot Alkaloids

A

Ergomar (ergotamine tartrate), Cafergot (Ergotamine and caffeine), dihydroergotamine

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14
Q

Ergot MOA

A

nonselective 5HT receptor 1 agonists. direct stimulating effect on peripheral smooth muscle and cranial blood supply. Vasoconstrictor

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15
Q

Dihydroergotamine MOA

A

5HT, NE, and DA receptors

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16
Q

Dihydroergotamine indications

A

acute migraine, cluster HA

17
Q

Ergot indications

A

abort or prevent vascular HA

18
Q

Ergot contraindications

A

Renal failure, hepative failure, vascular disease, HTN, pregnancy, breastfeeding, basilar or hemiplegic migraine

19
Q

Ergot ADR

A

St. Anthonys fire (HA, vomting, diarrhea, gangrene), ischemia (P450), abd pain, weakness, fatigue, myalgia, diarrhea, chest tightness

20
Q

Ergot drug interactions

A

other ergots, serotonin, p450 3A4 inhibitors, vasocontrictors

21
Q

Migraine prophylaxis

A

Divalproex sodium, Topiramate, Propranolol, Metoprolol, Timolol, Frovatriptan

22
Q

Natural Medicines

A

Butterbur

Pharmacology (33 decks)

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