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Pharmacology > Insomnia > Flashcards

Insomnia Flashcards

1
Q

Insomnia diagnostic criteria

A

symptoms cause significant functional distress or impairment, present for >3 nights per week for at least 3 months, not linked to other disorders

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2
Q

Sedative Hypnotics

A

Benzodiazepines- Temazepam, Triazolam

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3
Q

Temazepam indications

A

short term treatment up to 2 weeks

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4
Q

Triazolam indications

A

pre-op anxiety

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5
Q

Benzodiazepine receptor agonists MOA

A

binds GABA receptor at BDZ 1 site for targeted sedation

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6
Q

BDZ receptor agonist indications

A

first line short term treatment of insomnia

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7
Q

BDZ receptor agonists

A

Zolpidem (ambien), Eszopicolone (lunesta)

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8
Q

Zolpidem indications

A

sleep onset and sleep maintenance insomnia

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9
Q

Zolpidem ADR

A

Parasomnias, rebound insomnia, drowsiness, allergic reactions, angioedema, dry mouth, abdominal pain, HA, strange behavior

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10
Q

Zolpidem interactions

A

3A4 substrate, CNS depressants, EtOH

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11
Q

Eszopicolone indications

A

sleep latency and sleep maintenance

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12
Q

Eszopicolone ADRs

A

unpleasant taste, HA, infections, next day impairment, parasomnias, anaphylaxis, angioedema,

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13
Q

Eszopicolone interactions

A

CNS depressants, 3A4 substrate, EtOH

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14
Q

Zaleplon (sonata) indications

A

sleep latency and maintenance, can be taken nocturnal

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15
Q

Zaleplon ADR

A

HA, dizziness, somnolence, complex behavior, anaphylaxis

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16
Q

Melatonin MOA

A

hormone produced by pineal gland

17
Q

Melatonin indications

A

Sleep latency, Jet lag, insomnia

18
Q

Melatonin ADR

A

well tolerated, drowsiness, HA,

19
Q

Melatonin interactions

A

potentiates anticoag, inhibits AED

20
Q

Ramelteon MOA

A

melatonin receptor agonist

21
Q

Ramelteon indications

A

sleep latency

22
Q

Ramelteon ADR

A

somnolence, fatigue, dizziness

23
Q

Ramelteon contraindications

A

liver disease

24
Q

Tasimelteon

A

first treatment for non-24- hour sleep waked disorder

25
Q

Tasimelteon MOA

A

melatonin receptor agonists

26
Q

Tasimelteon ADR

A

somnolence, HA, increased LFT, nightmares, URI, UTI

27
Q

Tasimelteon interactions

A

CYP1A2 inhibitors, CYP3A4 inducers

28
Q

Suvorexant MOA

A

orexin receptor antagonist. Suppresses wake drive

29
Q

Suvorecant indications

A

sleep latency and sleep maintenance

30
Q

Suvorexant ADR

A

next day impairment, complex behaviors, depression, decreased resp, hallucinations, sleep paralysis

31
Q

Suvorexant contraindications

A

narcolepsy

32
Q

Doxepin

A

antidepressant with antihistamine effects

33
Q

Doxepin contraindication

A

urinary retention, glaucoma, MAOIs

34
Q

Doxepin ADR

A

suicide risk, daytime sedation, dry mouth, dry eyes, orthostasis, arrhythmias

35
Q

Antipsychotics

A

quetiapine, olanzapine

36
Q

Valerian Root

A

sedative-hypnotic, anxiolytic, antidepressant, anticonvulsant, antispasmodic

37
Q

Valerian Root ADR

A

HA, GI upset, mental dullness, excitability, uneasiness, cardiac disturbances, insomnia

38
Q

First line

A

CBT, Zolpidem, eszopiclone, suvorexant

Pharmacology (33 decks)

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