Antifungals Flashcards

1
Q

Classes

A

polyenes, imidazoles, antimetabolite

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2
Q

polyenes

A

amphitericin, nystatin

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3
Q

Polyene MOA

A

damages cell membranes

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4
Q

Polyene spectrum

A

broadest spectrum

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5
Q

amphitericin indications

A

life threatening fungal infections only due to side effects

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6
Q

Amphitericin ADR

A

nephrotoxicity, anaphylaxis, leukocephalopathy

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7
Q

Nystatin indications

A

candidiasis, diaper dermatitis

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8
Q

Azoles

A

ketoconazole, fluconazole, itraconazole, voriconazole, posiconazole

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9
Q

fluconazole

A

candidiasis

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10
Q

itraconazole

A

inhaled fungi

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11
Q

Voriconazole

A

invasive or serious infections of aspergillosis or candidiasis

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12
Q

posaconazole

A

pharyngeal candidiasis

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13
Q

ketoconazole

A

systemic severe infections

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14
Q

ketoconazole ADR

A

nervousness, somnolence, depression, impotence

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15
Q

Allyamine antifungals

A

terbinafine, naftifine

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16
Q

Terbinafine

A

oncychrimyosis

17
Q

naftifine

A

topical tinea treatment

18
Q

Flucytosine

A

misc antifungal- severe infections

19
Q

echinocandins

A

caspofungin, anidulafungin, micafungin

20
Q

Griseofulvin

A

indicated for tinea only