Antifungals Flashcards
Classes
polyenes, imidazoles, antimetabolite
polyenes
amphitericin, nystatin
Polyene MOA
damages cell membranes
Polyene spectrum
broadest spectrum
amphitericin indications
life threatening fungal infections only due to side effects
Amphitericin ADR
nephrotoxicity, anaphylaxis, leukocephalopathy
Nystatin indications
candidiasis, diaper dermatitis
Azoles
ketoconazole, fluconazole, itraconazole, voriconazole, posiconazole
fluconazole
candidiasis
itraconazole
inhaled fungi
Voriconazole
invasive or serious infections of aspergillosis or candidiasis
posaconazole
pharyngeal candidiasis
ketoconazole
systemic severe infections
ketoconazole ADR
nervousness, somnolence, depression, impotence
Allyamine antifungals
terbinafine, naftifine