Nervous System Flashcards
Sensory receptors
Detect stimulus
Motor effectors
Respond to stimulus
Central nervous system
Brain and spinal cord
Peripheral nervous system
Sensory and motor neurons
Somatic NS stimulates skeletal muscles
Autonomic NS stimulates smooth and cardiac muscles and glands
Somatic NS
Stimulates skeletal muscles
Autonomic NS
Stimulates smooth and cardiac muscles as well as glands
Sympathetic and parasympathetic NS
Counterbalance each other
Types of neurons
Sensory neurons, motor neurons, inter neurons
Sensory neurons
(Afferent neurons) carry impulses to CNS
Motor neurons
(Efferent neurons) carry impulses from CNS to effectors (muscles and glands)
Interneurons
(Association neurons) provide more complex reflexes and associative functions (learning and memory)
Components of a neuron
Cell body, dendrites, axon
Cell body
Enlarged part containing nucleus
Dendrites
Short cytoplasmic extensions that receive stimuli
Axon
Single long extension that conducts impulses away from cell body
Neuroglia
Support neurons structurally and functionally
Schwann cells and oligodendrocytes produce myelin sheaths
Myelinated axons in CNS
Form white matter. Dendrites/cell bodies form gray matter
Myelinated axons in PNS
Bundled to form nerves
Negative pole
Cytoplasmic side
Positive pole
Extra cellular fluid side
Resting potential of an I stimulated neuron
-70mV
Inside of the cell is more ____ charged than outside
Negatively
Sodium potassium pump
Brings two K+ into cell for every three Na+ it pumps out
Ion leakage channels
Allow more K+ to diffuse out than Na+ to diffuse in
Membrane is not permeable to
Negative ions
Equilibrium potential
Balance between diffusion all force and electrical force
Action potentials
Result when depolarization reaches the threshold potential (-55mV)
Depolarizations
Bring neuron closer to threshold
Hyperpolarization
Move neuron further from threshold
Action potentials are caused by
Voltage-gated ion channels
- voltage gated Na+ channels
- voltage gated K+ channels
Phases of an action potential
Rising, falling, undershoot
Action potentials are always
Separate, all-or-none events with the same amplitude
Two ways to increase velocity of conduction
Axon has large diameter, axon is myelinated (saltatory conduction)
Synapses
Specialized intercellular junctions with the other neurons, with muscle cells, or with gland (endocrine or exocrine) cells
Presynaptic cell
Transmits action potentials
Postsynaptic cell
Received action potentials
Two types of synapses
Electrical and chemical
Electrical synapses
Involved in direct cytoplasmic connections between the two cells formed by gap junctions
Rare in vertebrates
Chemical synapses
Have a synaptic cleft between two cells
End of presynaptic cell contains synaptic vesicles packed with neurotransmitters
In chemical synapses the neurotransmitter is released by
Exocytosis
In chemical synapses the neurotransmitter action is terminated by
Enzymatic digestion or cellular uptake
Acetylcholine
Crosses the synapse between a motor neuron and a muscle fiber
Neuromuscular junction
What does acetylcholine bind to
Receptor in postsynaptic membrane
What does acetylcholine produce
A depolarization called an excitatory postsynaptic potential
Stimulates muscle contraction
What degrades acetylcholine
Acetylcholinesterase
Causes muscle relaxation
Amino Acids
Glutamate
Glycine and GABA
Glutamate
Major excitatory neurotransmitter in vertebrate CNS
Glycine and GABA
Inhibitory neurotransmitters
Open ligand-gated channels for Cl-
What do glycine and GABA produce
Hyperpolarization called an inhibitory postsynaptic potential
Epinephrine and norepinephrine
Responsible for “fight or flight”
Dopamine
Used in some areas of the brain that control movements
Acts outside nervous system as paracrine messenger
Serotonin
Involved in regulation of sleep
Neuropeptides
Substance P released from sensory neurons activated by painful stimuli
Intensity of pain depends on enkephalins and endorphins
Nitric oxide
A neuropeptide
Produced as needed from arginine
Causes smooth muscle relaxation
2 ways for membrane to reach threshold voltage
Spatial summation and temporal summation
Spatial summation
Many different dendrites produce EPSPs
Temporal summation
One dendrite produces repeated EPSPs