nausea and vomiting pharm Flashcards
1
Q
Serotonin (5-HT3) Receptor Antagonists
A
- strong antiemetic
- end with “setron”
- risk of serotonin syndrome when combined with other 5HT affecting drugs
- dose dependent QT prolongation
2
Q
Dolasetron
A
- Serotonin (5-HT3) Receptor Antagonists
- high risk of dose dependent QT prolongation (Torsades)
3
Q
Granisetron
A
-Serotonin (5-HT3) Receptor Antagonists
4
Q
Ondansetron
A
-Serotonin (5-HT3) Receptor Antagonists
5
Q
Palonosetron
A
-Serotonin (5-HT3) Receptor Antagonists
6
Q
Neurokinin (NK1) Receptor antagonists
A
- end with “pitant”
- moderate antiemetic
- chemotherapy induced NV
- mild GI and CNS AE
7
Q
Aprepitant
A
- Neurokinin (NK1) Receptor antagonists
- PROPHYLAXIS of post-op NV
8
Q
Fosaprepitant
A
-Neurokinin (NK1) Receptor antagonists
9
Q
Netupitant
A
- Neurokinin (NK1) Receptor antagonists
- moderate CYP450 inhibitor
10
Q
Fosnetupitant
A
-Neurokinin (NK1) Receptor antagonists
11
Q
Rolapitant
A
- Neurokinin (NK1) Receptor antagonists
- moderate CYP450 inhibitor
12
Q
Histamine (H1) Receptor Antagonists
A
- weak antiemetic
- anticholinergic activities
- can cause dry mouth, drowsiness, constipation, urinary retention….
13
Q
Diphenhydramine
A
-Histamine (H1) Receptor Antagonists
14
Q
Dimenhydrinate
A
-Histamine (H1) Receptor Antagonists
15
Q
Hydroxyzine
A
-Histamine (H1) Receptor Antagonists
