Cancer Pharm Flashcards
1
Q
Cyclophosphamide
A
- alkylating agent (cell cycle NONspecific)
- form covalent G-G bonds in DNA
- prodrug, must be activated by CYP2B
- blood in urine, acrolein (prevent with mesna)
- nephrotoxicity
2
Q
Ifosfamide
A
- alkylating agent (cell cycle NONspecific)
- form covalent G-G bonds in DNA
3
Q
Busulfan
A
- alkylating agent (cell cycle NONspecific)
- form covalent G-G bonds in DNA
- pulmonary fibrosis
4
Q
Cisplatin
A
- alkylating agent (cell cycle NONspecific)
- form covalent G-G bonds in DNA
- MELANOMA
- renal tubular damage, ototoxicity
5
Q
Methotrexate
A
- Antimetabolite (cell cycle specific)
- Inhibits dihydrofolatereductase
- mucositis
6
Q
Leucovorin
A
- rescue for methotrexate toxicity
- continues folate pathway
7
Q
5-Flourouracil
A
- Antimetabolite (cell cycle specific)
- PYRIMIDINE structural analog
8
Q
6-Mercaptopurine
A
- antimetabolite (cell cycle specific)
- PURINE structural analog
9
Q
Vinblastine
A
- natural product (cell cycle specific)
- Bind to β-tubulin and inhibit microtubule assembly
- mitosis inhibition
10
Q
Vincristine
A
- natural product (cell cycle specific)
- Bind to β-tubulin and inhibit microtubule assembly
- mitosis inhibition
- peripheral neuropathy
11
Q
Paclitaxel
A
- natural product (cell cycle specific)
- Bind to β-tubulinand stabilize microtubule formation
- Hypersensitivity reactions in hands and toes, change in taste
12
Q
Etopside
A
- natural product (cell cycle specific)
- topoismerase II inhibitor
13
Q
Topotecan
A
- natural product (cell cycle specific)
- Topoisomerase I inhibitor
14
Q
Doxorubicin
A
- natural product (cell cycle NONspecific)
- topoismerase II inhibitor
- cardiotoxicity
15
Q
Bleomycin
A
- natural product (cell cycle specific)
- Single- and double-stranded DNA breaks
- pulmonary toxicity
