Drugs for ANCA Diseases

Question 1

cyclophosphamide

Answer 1

-alkylating drug used for cancer, minimal change dz,
and ANCA vasculitis
-do not use if there is a urinary flow obstruction
-risk of fetal toxicity, immunosuppression, cardiopulm toxicity

Question 2

rituximab

Answer 2

• CD-20 directed cytolytic antibody used in NHL, CLL, and RA
• risk of fetal toxicity, tumor lysis syndrome, progressive multifocal enchephalopathy, and renal toxicity when used with cisplatin
• high rate of adverse rxn in lymphoid malignancies, and RA

Question 3

azathioprine

Answer 3

• used in the prevention of rejection in renal transplant patients and in RA
• do not use in pregnant patients, or patients with RA that were previously treated with alkylating agents
• increased risk of skin cancer and lymphomas