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Various Pharm > Antidepressant Drugs > Flashcards

Antidepressant Drugs Flashcards

1
Q

citalopram

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • LITTLE EFFECT on histamine, muscarinic, or adrenergic receptors
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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2
Q

escitalopram

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • LITTLE EFFECT on histamine, muscarinic, adrenergic receptors, or CYP450
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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3
Q

fluoxetine

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • INHIBITS CYP450
  • LITTLE EFFECT on histamine, muscarinic, or adrenergic receptors
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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4
Q

paroxetine

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • LITTLE EFFECT on histamine, muscarinic, or adrenergic receptors
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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5
Q

sertraline

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • LITTLE EFFECT on histamine, muscarinic, or adrenergic receptors
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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6
Q

vilazodone

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT
  • ALSO a partial agonist at 5-HT1a receptor
  • LITTLE EFFECT on histamine, muscarinic, or adrenergic receptors
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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7
Q

vortioxetine

A
  • SSRI
  • selectively inhibit pre-synaptic reuptake of 5-HT\
  • ALSO a partial agonist at 5-HT1b, and a FULL agonist at 5-HT1a and 5-HT1d3,7 receptors
  • LITTLE EFFECT on histamine, muscarinic, adrenergic receptors, or CYP450
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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8
Q

amitryptyline

A
  • TCA and SNRI
  • 3° amine (inhibit NE<5-HT)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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9
Q

clomipramine

A
  • TCA and SNRI
  • 3° amine (inhibit NE<5-HT)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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10
Q

doxepin

A
  • TCA and SNRI
  • 3° amine (inhibit NE/5-HT equally)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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11
Q

imipramine

A
  • TCA and SNRI
  • 3° amine (inhibit NE/5-HT equally)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • used for ENURESIS
  • risk of coma, cardiotoxicity, convulsions
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12
Q

amoxapine

A
  • TCA and SNRI
  • 2° amine (inhibit NE>5-HT)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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13
Q

desipramine

A
  • TCA and SNRI
  • 2° amine (inhibit NE>5-HT)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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14
Q

nortriptyline

A
  • TCA and SNRI
  • 2° amine (inhibit NE>5-HT)
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of coma, cardiotoxicity, convulsions
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15
Q

desvenlafaxine

A
  • SNRI
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
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16
Q

duloxetine

A
  • SNRI
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • used for Diabetic Peripheral Neuropathy, Fibromyalgia, Chronic musculoskeletal pain, and stress incontinence
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
17
Q

venlafaxine

A
  • SNRI
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
18
Q

levomilnacipran

A
  • SNRI
  • selectively inhibit pre-synaptic reuptake of 5-HT and norepinephrine
  • risk of SUICIDE, SEROTONIN SYNDROME, CNS depression, decreased libido, weight gain, ACUTE withdrawal rxns
19
Q

trazodone

A
  • SARA
  • acts like SSRI and also blocks post synaptic α1 receptors, 5-HT2 receptors, and H1 receptors
  • causes sedation and priapism
  • risk of orthostatic hypotension
20
Q

nefazodone

A
  • SARA
  • acts like SSRI and also blocks post synaptic α1 receptors, 5-HT2 receptors, and H1 receptors
  • causes sedation
21
Q

mirtazapine

A
  • SARA
  • acts like SSRI and also blocks presynaptic α2 receptors, 5-HT2/3 receptors, and H1 receptors
  • risk of weight gain
22
Q

buproprion

A
  • NDRI
  • selectively inhibits reuptake of NE and DA on presynaptic neurons
  • enhances release of NE and DA via VMAT2 effects
  • used for NICOTINE WITHDRAWAL and as a stimulating drug
  • risk of agitation, weight loss, and SEIZURE
23
Q

isocarboxazid

A
  • MAOI
  • increases the amount of NE, DA, and 5-HT in vesicles and the amount released
  • risk of serotonin syndrome when taken with other antidepressants or tyramine containing foods
24
Q

phenelzine

A
  • MAOI
  • increases the amount of NE, DA, and 5-HT in vesicles and the amount released
  • risk of serotonin syndrome when taken with other antidepressants or tyramine containing foods
25
Q

selegiline

A
  • MAOI
  • MAO-B selective, given as transdermal patch
  • increases the amount of NE, DA, and 5-HT in vesicles and the amount released
  • risk of serotonin syndrome when taken with other antidepressants or tyramine containing foods
26
Q

tranylcypromine

A
  • MAOI
  • increases the amount of NE, DA, and 5-HT in vesicles and the amount released
  • risk of serotonin syndrome when taken with other antidepressants or tyramine containing foods
27
Q

esketamine

A
  • NMDA receptor antagonist
  • used in treatment resistant depression w/ ongoing antidepressant therapy
  • intranasal administration
  • need to watch pt for BP change, and dissociation, sedation
28
Q

brexanolone

A
  • GABAa receptor positive allosteric modulator
  • used in post-partum depression
  • 60-hr IV administration, lasts up to 30 days
  • need to watch pt for somnolence, and loss of consciousness
29
Q

carbamazepine

A
  • mood stabilizer
  • anti-seizure drug
  • used in acute and maintenance of mixed episodes in bipolar I
  • CYP450 inducer
30
Q

lamotrigine

A
  • mood stabilizer
  • anti-seizure drug
  • used in maintenance of bipolar I and II
31
Q

divalproex/valproic acid

A
  • mood stabilizer
  • anti-seizure drug
  • used for bipolar I
32
Q

lithium

A
  • mood stabilizer
  • maintenance of mania, and reduced suicide risk
  • inhibits DA transmission which helps manic episodes
  • downregulates NMDA receptor
  • promotes GABAergic transmission
  • risk of nephrogenic diabetes insipidus, drug interactions with diuretics, ACEIs, NSAIDs
  • narrow therapeutic window

Various Pharm (44 decks)

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