Drugs for Thyroid disease

Question 1

levothyroxine

T4

Answer 1

• thyroid hormone replacement
• treats hypothyroidism
• converted to T3
• cholestyramine prevents uptake

Question 2

liothyronine

T3

Answer 2

• thyroid hormone replacement

- treats hypothyroidism

Question 3

liotrix

Answer 3

-4:1 ratio of T4:T3

Question 4

thyroid dessiccated

Answer 4

• thyroid hormone replacement

- treats hypothyroidism

Question 5

radioactive iodine

131-I

Answer 5

• therapy for thyroid cancer
• destroys thyroid gland
• CONTRAINDICATED in pregnancy

Question 6

potassium iodide

Answer 6

• anti-thyroid drug

- blocks iodine uptake, protects thyroid from radiation

Question 7

methimazole

Answer 7

• anti-thyroid drug
• used to treat hyperthyroidism by blocking TPO and therefore iodide organification
• risk of jaundice, encephalopathy, and death

Question 8

propylthiouracil (PTU)

Answer 8

• anti-thyroid drug

- used to treat hyperthyroidism in patients who are intolerant of methimazole

Question 9

propranolol

Answer 9

• Beta-blocker

- used in thyroid storm to prevent conversion of T4 to T3

Question 10

amiodarone

Answer 10

• causes iatrogenic thyrotoxicosis

- contains large amounts of iodine which can be made into T3/T4