Drugs for Osteoporosis and Gout Flashcards
1
Q
calcium salts
A
- found in multivitamins
- treat hypocalcemia
2
Q
ergocalciferol
A
- Vitamin D2
- occurs in plants and used to fortify foods
3
Q
Cholecalciferol
A
- Vitamin D3
- produced when sunlight hits the skin
4
Q
calcitonin-salmon
A
- similar to human calcitonin
- inhibits osteoclasts and decreases bone resorption
- does not prevent osteoporosis
5
Q
alendronate
risendronate, ibandronate, tiludronate
A
- bisphosphonate
- decreases bone resorption by decreasing both the number and activity of osteoclasts
- risk of esophagitis, osteonecrosis of the jaw, and atypical femur fractures
6
Q
zolendronic acid
A
- bisphosphonate
- given IV once per year
- avoids GI problems
- most associated with osteonecrosis of the jaw
7
Q
raloxifene
A
- selective estrogen receptor modulator SERM
- enhances estrogen effect in bone, and blocks its effect in uterus and breast
- used to prevent osteoporosis of postmenopause
- risk of DVT, stroke
8
Q
teriparatide (PTH 1-34)
A
- truncated PTH
- only drug for osteoporosis that increases bone formation
- given in pulsed therapy, once daily with pre-filled injectors
9
Q
denosumab
A
- RANKL inhibitor
- decreases formation of osteoclasts
- used in postmenopausal osteoporosis
- injected SQ every 6 months
- delays fracture healing and risk of skin effects
10
Q
cinacalcet
A
- calcimimetic drug
- binds calcium receptors on PT gland
- treatment for hyperparathyroidism
11
Q
- clindamycin
- rifampin
- TMP-SMX
- fluoroquinolone
A
-osteomyelitis treatment
12
Q
colchicine
A
- gout treatment
- blocks microtubule formation
- prevents the proper function of phagocytes
- risk of GI distress
13
Q
allopurinol
A
- inhibits xanthine oxidase
- competitive inhibitor
- recurrent gout, or gout of chemotx
- risk of SJS-TEN
14
Q
febuxistat
A
- inhibits xanthine oxidase
- noncompetitive inhibitor
- recurrent gout, or gout of chemotx
15
Q
peglodicase
A
- recombinant uricase
- converts uric acid to allantoin
- treatment of chronic gout
- risk of infusion rxn
