Drugs for Interstitial Lung Disease

Question 1

Prednisone

Answer 1

• Used as an anti-inflammatory or immunosuppressive agent
• Also, used for the treatment of certain endocrine conditions
• Risk of hypothalamic-pituitary-adrenal (HPA) axis suppression, fluid retention, and elevated BP

Question 2

Mycophenolate

Answer 2

• an immunosuppressive drug
• used for prophylaxis of organ rejection, rheumatoid arthritis
• risk of fetal harm

Question 3

Methotrexate

Answer 3

• Anti-neoplastic
• used for neoplasia, psoriasis, rheumatoid arthritis
• risk of fetal death, marrow suppression, hepatotoxicity, lung dz

Question 4

Azathioprine

Answer 4

• immunosuppressive antimetabolite
• used in prevention of rejection after renal transplant, RA, and ILD
• risk of malignancy

Question 5

Nintedanib

Answer 5

• kinase inhibitor
• used in the treatment of idiopathic pulmonary fibrosis
• risk of fetal toxicity, liver damage, GI issues