Molar Pregnancy

Question 1

define

Answer 1

non-viable fertilised egg due to gestational trophoblastic disease

Question 2

what happens in a molar pregnancy?

Answer 2

there is overgrowth of placental tissue with chorionic villi swollen with fluid (grape-like clusters)

Question 3

classification

Answer 3

1. complete mole

2. partial mole

Question 4

what is a complete mole?

Answer 4

single or two sperm combine with an egg that has lost its DNA, the sperm re-duplicates to make 46 chromosomes (only paternal DNA present)

Question 5

what is a partial mole?

Answer 5

egg is fertilised by 2 sperm or by 1 sperm that duplicates yielding 69XXY, both maternal and paternal DNA is present

Question 6

what are complete hydatidiform moles at high risk of developing into?

Answer 6

choriocarcinoma (malignant tumour of trophoblasts)

Question 7

presentation

Answer 7

hyperemesis
hyperthyroidism
early onset pre-eclampsia
varied bleeding
occasional passage of grape-like tissue
abdominal pain
SOB (embolisation to the lungs)
seizure (metastasis to the brain)

Question 8

diagnosis

Answer 8

USS snowstorm appearance
described as frogspawn when expelled
+/- foetus, theca lutein cysts

Question 9

management

Answer 9

surgery= uterine evacuation and tissue sent to histology

can do medical management in partial