Microbiology: Pandemic Flu/Antivirals/Opportunistic Infections

Question 1

Pandemic Flu:

What is the causative virus of flu?

What are the 3 anti genetically different flus?

Answer 1

Question 2

Pandemic Flu:

What is a natural reservoir of Influenza A?

What is H5N1?

What are the ideal situations for flu to grow?

Answer 2

Question 3

Pandemic Flu:

What are the RNA segments?

What is the effect of neuraminidase?

What is the effect of haemogglutimin?

Answer 3

Question 4

Pandemic Flu:

What is Antigenic drift?

Answer 4

Question 5

Antivirals:

What is the mechanism of action of for:

1. Acyclovir
2. Ganciclovir

What are the symptoms of CMV?

Answer 5

Question 6

Antivirals:

What is used if there is resistance to Ganciclovir?

Answer 6

Question 7

Antivirals:

What is the machoism of action of Cidofovir?

What is the effect of Foscarnet & Cidofovir?

Answer 7

Question 8

Antivirals:

What is the treatment of Herpes Simplex Infection (HSV)?

Answer 8

Question 9

Antivirals:

What is the treatment for CMV in BMT?

Answer 9

Question 10

Antivirals:

What is the treatment for Hepatitis B Virus (HBV) based on?

Answer 10

Question 11

Antivirals:

What are the goals in Hepatitis B treatment?

Answer 11

Question 12

Antivirals:

What are the drugs given in Hepatitis B treatment?

Answer 12

Nuceloside Analogues: “LEATT”

• Lamivudine
• Entecavir
• Adefovir dipivoxil
• Telbivudine
• Tenofovir (Inhibitor of reverse transcriptase, the rest are inhibitors of viral polymerase)

Preferred 1st line: “PET”

• PegINF alpha 2a
• Entecavir
• Tenofovir

Question 13

Antivirals:

What are the treatment goals in Hepatitis C treatment?

Answer 13

Question 14

Antivirals:

What are the genotypes affecting outcomes in Hepatitis C treatment?

Answer 14

Question 15

Antivirals:

What is is the treatment for Respiratory Viruses?

Answer 15

Question 16

Pandemic Flu:

What is Antigenic shift?

Answer 16

HA = Haemagglutinin

NA = Viral Neuraminidase

Question 17

Pandemic Flu:

What is the pathogenesis of Influenza?

Answer 17

HA = Haemagglutinin

Question 18

Pandemic Flu:

What is are the causes of severe outcomes in Flu?

Answer 18

Question 19

Pandemic Flu:

What are the antivirals used in Flu?

Answer 19

Question 20

Opportunistic Viral Infections:

What are the stages of PCR?

Answer 20

Question 21

Opportunistic Viral Infections:

Who is affected by opportunistic viral infections?

What are the types of immunodeficiencies?

Answer 21

Question 22

Opportunistic Viral Infections:

What are the 3 origins of opportunistic viral infections?

Answer 22

Question 23

Opportunistic Viral Infections:

Where do VZV/HSV remain dormant?

Where do EBV/CMV remain dormant?

Answer 23

Question 24

Antivirals:

What are the drugs given in Hepatitis C treatment?

Answer 24

Question 25

Opportunistic Viral Infections:

What are the most important characteristics of VZV?

Answer 25

Question 26

Opportunistic Viral Infections:

What are the most important characteristics of CMV?

Answer 26

Question 27

Opportunistic Viral Infections:

What are the most important characteristics of EBV?

Answer 27

Question 28

Opportunistic Viral Infections:

What are the most important characteristics of HHV8?

Answer 28

Question 29

Opportunistic Viral Infections:

What are the most important characteristics of HHV6?

Answer 29

Question 30

Opportunistic Viral Infections:

What are the most important characteristics of Adenovirus?

Answer 30

Question 31

Opportunistic Viral Infections:

What are the most important characteristics of Measles?

Answer 31