Haematology: Haemostasis/Bleeding Disorders/VTE

Question 1

Haemostasis

Outline the main processes in forming a stable Haemostatic plug

Answer 1

Question 2

Haemostasis

Outline the main steps of the Coagulation cascade

Answer 2

Question 3

Blood tests for Coagulation disorders:

Outline the results for INR, APTT, Thrombin time, Platelet count and Bleeding time for:

1. Heparin
2. DIC
3. Liver Disease
4. Platelet defect
5. Vit K Deficiency
6. Haemophilia
7. vWF Disease

Answer 3

Question 4

Venous Thrombosis

Outline the main risk factors for and causes of Venous Thromboembolism (VTE)

Answer 4

Question 5

Haemostasis:

What are the phases of haemostasis?

Answer 5

Question 6

Haemostasis:

What are the key inhibitors of haemostasis?

Answer 6

Question 7

Haemostasis:

What does the Activated partial thromboplastin (APTT) measurement track?

Answer 7

Question 8

Haemostasis:

What does the Prothrombin time (PT) measurement track?

Answer 8

Question 9

Haemostasis:

What does the Thrombin time (TT) measurement track?

Answer 9

Question 10

Bleeding disorders:

What are the causes of bleeding disorders and what are the features of Vascular and Coagulation disorders?

Answer 10

Question 11

Bleeding disorders:

What are the main vascular defect bleeding disorders?

Answer 11

Question 12

Bleeding disorders:

What are the main causes of platelet disorders?

Answer 12

Question 13

Bleeding disorders:

What is/are the peak age, F:M ratio, preceding infection, onset of symptoms, platelet count, duration and spontaneous remission of Acute ITP and Chronic ITP?

Answer 13

Question 14

Bleeding disorders:

What is/are the epidemiology, genetics and presentation of Haemophilia A?

Answer 14

Question 15

Bleeding disorders:

What is/are the investigations and management of Haemophilia A?

Answer 15

Question 16

Bleeding disorders:

What are the features of Haemophilia B?

Answer 16

Question 17

Bleeding disorders:

What is/are the subclasses and genetics of Von Willebrand’s disease?

Answer 17

Question 18

Bleeding disorders:

What is/are the presentation, diagnosis and management of Von Willebrand’s disease?

Answer 18

Question 19

Bleeding disorders:

Acquired coagulation disorders: What is/are the aetiology, investigations and management of Disseminated intravascular coagulation (DIC)?

Answer 19

Question 20

Bleeding disorders:

Acquired coagulation disorders: What are the effects of liver disease on coagulation?

Answer 20

Question 21

Bleeding disorders:

Acquired coagulation disorders: What is/are the aetiology and treatment of Vitamin K Deficiency on coagulation?

Answer 21

Question 22

Bleeding disorders:

Outline the prophylactic treatment of VTE

Answer 22

Question 23

Bleeding disorders:

Outline the treatment of DVT/PE

Answer 23

Question 24

Bleeding disorders:

What is the mechanism of action of Heparin?

What is its antidote?

Answer 24

Question 25

Bleeding disorders:

What is the mechanism of action of Warfarin?

What is its antidote?

Answer 25

Question 26

Bleeding disorders:

What are the indications for target INRs of 2.5 and 3.5?

Answer 26

Question 27

Bleeding disorders:

What is the protocol for INR levels of:

1. 5 to 8, no bleeding
2. 5 to 8 bleeding
3. >8 no bleeding/minor bleed
4. Major bleeding (including intracranial haemorrhage)

Answer 27