lecture 7 Flashcards

1
Q

prevalence

A

proportion of a population who have a specific characteristic in a given time period

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2
Q

how us estimated prevalence calculated

A

if you know info on the samples of the population of interest

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3
Q

how is prevalence calculated

A

if info of the entire population is provided

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4
Q

prevalence in uk

A

4.1 per 1000

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5
Q

prevalence gender

A

affects men slightly more often than women

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6
Q

onset

A

late adolescence and early adulthood

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7
Q

estimated annual prevalence uk

A

0.4 or 4 per 1000

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8
Q

incidence

A

a measure of the number of new cases of a characteristic that arise in a population over a given period

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9
Q

cost of psychosis per year

A

£11.8 billion a year

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10
Q

other psychotic disorders

A

schizoaffective disorder, delusional disorder and schizophreniform disorder and brief psychotic disorder

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11
Q

schizoaffective disorder symptoms of

A

both schizophrenia and mood disorder - rewires having a major depressive or mania episode

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12
Q

delusional disorder

A

having delusions -persecution , jealousy , grandeur - no other symptoms of schizophrenia

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13
Q

schizophreniform disorder

A

symptoms must include either delusions hallucinations or disorganised speech

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14
Q

schizophreniform disorder duration

A

greater than 1 month but less than 6 months

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15
Q

brief psychotic disorder

A

symptoms must include either hallucinations, delusions or disorganised speech

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16
Q

brief psychotic disorder duration

A

1 day to 1 month

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17
Q

brief psychotic disorder triggered bt

A

extreme stress or bereavement

18
Q

behavioural genetic studies show that schizophrenia is

A

substantially heritable - 80% of the variance in schizophrenia scores is estimated to be attributable to genetic factors

19
Q

heritability

A

proportion of variance that is accounted by genetic factors in a given population

20
Q

example study of twin study

A

estimated heritability 79%

concordance rate - 33% for MZ twins and 7% for DZ` Twins

21
Q

concordance

A

presence of the same trait in both members of the pair twins

22
Q

family studies

A

first degree relatives are 18 times are likely to develop schizophrenia

23
Q

gottesman

A

MZ- 48%

DZ-17%

24
Q

The genain quadruplets

A

all four developed schizophrenia

25
genes associated with schizophrenia
COMT, BDNF, DRD2
26
COMT
associated with executive functioning that rely on prefrontal cortex
27
BDNF
brain derived neurotrophic factor is critical for the survival of the CNS
28
drd2
dopamine receptor d2 is a protein that in humans is encoded by the DRD2 gene
29
genome wide association study
GWAS - hypothesis free methods to identify associations between genetic regions -loci and traits- genetics
30
enlarged lateral ventricles
fluid filled spaces - implies loss of Brian cells - social behavioural and emotional deficits
31
decreased prefrontal Brain function
important in language , emotional expression , planning and carrying out plans
32
hippocampus
learning and emotions
33
amygdala
emotional response , decision making
34
thalamus
relaying sensory and motor signals
35
reduced
grey matter and volume evident
36
birth complications
perinatal hypoxia | prenatal viral exposure
37
perinatal hypoxia
oxygen deprivation at birth- as many as 30% of people with schizophrenia have a history of this
38
prenatal viral exposure
rates were higher when mother had flu in second trimester- critical period of development of CNS
39
viral infections
mothers immune system to be more active- negatively impact development of brain cells and dopamine systems in the foetus
40
dopamine theory
disorder due to excess levels of dopamine
41
drugs that alleviate symptoms
reduce dopamine activity. if induces - increase dopamine- induce psychosis