lecture 4 Flashcards
aetiology
study of the causation/origination of a disorder
diathesis stress model
genetics and environment
heritability twin studies
37% for MDD
93% for bipolar disorder
2 polymorphisms related to vulnerability to develop MDD
polymorphism of the serotonin transporter gene and DRD4-2 gene- influence of dopamine
neurotransmitters initial assumption
absolute level of serotonin , dopamine in the synaptic cleft are associated with mood disorders either too high or low
depression is associated with
low dopamine and serotonin
mania is associated with
high dopamine and low serotonin
people with insensitive receptors experience
depressive symptoms as levels of serotonin drop
amygdala processes
emotions particularly fear- help assess how emotionally important a stimulus is
hippocampus what kind of activity for people with depression
diminished
overactivity in amygdala means
oversensitivity to emotionally relevant stimuli
hippocampus is related to
learning and memory
hpa axis does not seem to respond well to
biological signals to decrease cortisol levels
over secretion of cortisol results in
more people experiencing depressive symptoms
animal study evidence
cortisol levels high = depressive symptoms