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Bacteriology > Lecture 29 - Lawsonia > Flashcards

Lecture 29 - Lawsonia Flashcards

1
Q

What species are present in the genus Lawsonia?

A

Intracellularis

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2
Q

What are that basic characteristics of L. Intracellularis?

A

Non-spore forming
Microaerophilic
Curved-shaped bacillus
Obligate intracellular

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3
Q

What is the structure of the membrane of L. Intracellularis?

A

Trilaminar

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4
Q

What other bacteria has a trilaminar membrane?

A

Mycoplasma

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5
Q

What is needed to grow L. Intracellularis?

A

Cell-free media doesnt work

Dividing cell culture needed with microaerophilic atomosphere

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6
Q

What is the method by which L. Intracellularis gets into its host?

A

Adheres to enterocytes then invades them

Leaves the phagosome and hangs out in the cytoplasm of the enterocyte

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7
Q

What does L. Intracellularis do to enterocytes?

A

Induces hyperplasia

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8
Q

What immune response occurs with L. Intracellularis infections?

A

None really

See no real inflammation at site of infection and T/B cell response is reduced

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9
Q

how is L. Intracellularis transmitted?

A

Fecal-Oral

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10
Q

What are the three major results see in the host due to the hyperproliferation caused by L. Intracellularis?

A

Thickening of the mucosa = hypertrophy
Increased non-functioning crypt cells = malabsorption
Fecal shedding

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11
Q

What animals is proliferative enteropathy an emerging disease?

A

Horses

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12
Q

Where was proliferative enteropathy first seen?

A

Pigs

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13
Q

What is the model for horse?

A

Rabbit

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14
Q

What is the model for pigs?

A

Hamster

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15
Q

What lesions are seen with L. Intracellularis infections?

A

Intestinal hyperplastic lesions

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16
Q

What is thought to be the carrier host of L. Intracellularis?

A

Dogs

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17
Q

Why are dogs though to be the carrier host of L. Intracellularis?

A

Have serum antibodies present for L. Intracellularis even without disease

18
Q

What form of L. Intracellularis infection is most common in pigs?

A

Chronic

19
Q

What are the reserviors for L. Intracellularis in pig populations?

A

Rats + Mice

20
Q

When do you see clinical L. Intracellularis disease in pigs?

A

With stress

21
Q

What are the two presentations of the chronic form of L. Intracellularis seen in pigs

A

PIA
– and –
PHE

22
Q

Term: PIA

A

Porcine Instestinal adenomatosis

23
Q

What age does PIA occur?

A

6 to 20 weeks

24
Q

What symptoms are seen with PIA?

A

Water to pasty, brownish blood stained poop
Poor growth
Can recover spontaneously

25
Q

What is seen with severe PIA?

A

Coagulative necrosis of adenomatous mucosa

Can recover spontaneously

26
Q

Term: PHE

A

Proliferative hemorrhagic enteropathy

27
Q

When is PHE seen?

A

4 to 12 months

28
Q

What symptoms are seen with PHE?

A

Cutaneous pallor + Weakness
Black tarry feces
Die quick

29
Q

What are the differential diagnosis for PHE?

A

Swine dysentery
Gastric ulcers
Salmonella

30
Q

What are the resiviors in horse populations?

A

Rabbits

31
Q

What is the window of risk seen in weanling horses?

A

Decreased colostrum Ab’s
– and –
Mounting own cell-mediated response
plus have a lot of stress

32
Q

What symptoms area seen in horses with L. Intracellularis infections?

A

Lethargy + Anorexia + Fever
Hypoproteinemia + Hypoalbunemia
Peripheral edema!!

33
Q

What are the differiential diagnosis for horses with L. Intracellularis infections?

A

Parasitism
Bacterial infection
Viral infection
Plant toxicity

34
Q

What bacterial infections can look like L. Intracellularis?

A

Clostridium
Salmonella
Rhodococcus

35
Q

What is the preferred method of confirmation of a L. Intracellularis infection in both horses and pigs?

A

IPMA - immunoperoxidase monolayer assay

36
Q

What is done diagnostically in horses only when a L. Intracellularis infection is suspected?

A

Blood work + Ultrasound

37
Q

What special stain is used for L. Intracellularis?

A

Warthin-Starry sliver stain

38
Q

What is the treatment for L. Intracellularis?

A

Oxytetracycline + Doxycyline

39
Q

What characteristics of an AB must be present to treat L. Intracellularis?

A

Lipophilic or aamphoteric to concerntrate in host cytoplasm

40
Q

What vaccine is avalible for L. Intracellularis? Why is this different?

A

Pigs - take orally in drinking water
Horses - rectally
ITS THE SAME VACCINE

Bacteriology (28 decks)

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