Lecture 24 - Treponema, Actinobacillus, and PANSF Flashcards
What are the four treponema species of importance?
Paraluiscuniculi
Phagedenis
Vincentii
Denticola
What Treponema ssp. occurs in rabbits? How does it present?
Paraluiscuniculi = Vent disease
What Trepomnema causes lameness in cattle and sheep?
Phagedenis
Vincentii
Denticola
What type of bacteria is Treponema?
Spirochete
What is the pathology of bovine digital dermitis?
Interdigital inflammatory lesions
Proliferative dermatitis on bulbs of heels
When do you see bovine digital dermatitis the most?
First-calved heifers
What are the two forms of bovine digital dermatitis?
Erosive + Verrucose
What is the bovine digital dermatitis form in the US?
Verrucose
What is the bovine digital dermatitis from in the UK?
Erosive
What is the scoring system for bovine digital dermatitis?
M1 (mild) –> M4 Chronic
Term: M1
Early, small epithelial defects
Red to gray
Term: M2
Acute, active ulcerative lesion
White halo
Lesion has scab
Term: M3
Healing stage
1-2 days after topical therapy
Term: M4
Chronic stage, thicken epithelium
Scabbed or filamentous
Several cm in diameter
What is the pathology of ovine digital dermatitis?
Mildly virulent form of footrot
Seperation of hoof horn
Ulcerative lesions on coronary band
How do you tell Bovine and Ovine digital dermatitis apart?
Bovine = interdigital lesions Ovine = Coronary band lesions
What other bacteria can be present with ovine dermatitis?
Dichelobacter nodosus
How is vent disease diagnosed?
VDRL slide test
Why is it hard to diagnose treponema?
Multifactorial infections
What color does Treponema stain with FISH?
Yellow
What is the treatment for Bovine digital dermatitis?
oxytetracycline
No vaccines
Footbaths = Linco + erthryo + oxytetracycline
What is used to treat vent disease?
Penicillin
How is ovine contagious digital dermatitis treated?
No real treatment
What type of bacteria is actinobacillus?
Gram(-)
Coccobacilli
What are enzymatic properties of actinobacillus?
Ferment carbs (not lactose)
Urease +
Oxidase +
Where is actinobacillus normally found?
Mucous membranes
URT + Oral cavity
How long can actinobacillus make it in the environment?
Can’t host transmission is VITAL
What are the species of actinobacillus?
Pleuropneumonia Equuli Suis Seminis Lingineresii
Animals: Pleuropneumonia
Pigs
Animals: Equuli
Horse + Pigs + Cattle
Animals: Suis
Pigs + Horses
Animals: Seminis
Sheep + Goat
What allows A. pleuropneumoniae to attach to epithelial cells?
LPS + Fimbria
Where does A. pleuropneumoniae like to survive in host?
Macrophages
– and –
Rapidosomes
What allows A. pleuropneumoniae from being phagostize?
Capsule
What are the four cytotoxins that A. pleuropneumonia contain?
APX I-IV
What do the Apx cytotoxins do?
Create pores in hosts cells
Release of inflammatory mediators
Call in neutrophils to infected pulmonary tissue
What happens to Neutrophils once they reach the pulmonary tissue in an A. Pleuropneumonia infection?
Damaged by toxins
Release lytic enzyme –> tissue damage
Where does A. Pleuropneumonia localize in pigs?
Colonize tonsils