Lecture 27 - Bartonella Flashcards
What are the structural characteristics of Bartonella?
Small, thin curved rods
Gram negative
What cell type for Bartonella have an affinity for?
Blood + Vascular endothelial cells
What type of pathogen is Bartonella?
Facultative intracellular pathogen
Which Bartonella is the only one not found worldwide? Where is it found?
B. Bacilliformis
South America
What are the three Bartonella we are concerned with?
Elizabethae
Vinsonii ssp. Berkoffii
Henselae
Species: Elizabethae
Rates
Species: Vinsonii ssp. Berkoffii
Dog
Species: Henselae
Cats
What carries the B. henselae bacteria?
Cat flea
What is the cat flea?
Ctenocephalides felis
What is the mechanism by which the B. Henselae is transferred from the flea to the cat?
Flea feces adhere to cat claws
What is the clincal presentation of B. Henselae in cats?
None
What are other two Bartonella, not including Henselae, that can cause Cat Scratch disease?
Clarridgeiae
– and –
Koehlerae
Where is CSD most common?
Tropical regions, does best in warmer climates
What causes cat scratch disease?
B. Henselae infect VES cells + Lymph nodes in humans
What can occur in people who are immunocompromised that are exposed to B. Henselae?
Bacteremia + Septicemia
How long does it take chronic regional lymphadenopathy to occur?
3 to 50 day s
How long does chronic regional lymphadenopathy stick around?
Months
What can happen to LN in humans that are infected with B. Henselae?
Hyperplasia + Granuloma formation + Suppuration
Which Bartonella causes bacillary angiomatosis?
B. henselae
– or –
B. Quintana
What is the characteristics of bacillary angiomatosis when B. Henselae is responsible?
Involves:
Skin + Liver + Spleen + Lymph Nodes
What is the characteristics of bacillary angiomatosis when B. Quintana is responsible?
Involves:
Skin + SQ + Bone
What is used to stain Bartonella?
Warthin-starry silver stain
What is the treatment for Bartonella?
Cat - doxycycline for 2 to 4 weeks
