L1: Anemia - Aplastic Anemia Flashcards
Def of Aplastic Anemia
Hematological disorder characterized by BM failure (decrease or absence of blood-forming elements)
- Pancytopenia and replacement of bone marrow by fatty tissue
Def of Hypoplastic Anemia
The impairment usually involves mainly the RBCs
Etiology of Aplastic Anemia
Etiology of Aplastic Anemia
- congenital
Cause of Fanconi Anemia
- AR disease → Defect in genes coding for DNA repair enzymes
CP of Fanconi Anemia
Dx of Fanconi Anemia
Chromosomal breakage test
Def of Diamond - Blackfan anemia
Congenital pure red cell aplasia
Etiology of Aplastic Anemia
- Acquired
Acquired Causes of Aplastic Anemia
- 1ry
Idiopathic (90% of cases)
Acquired Causes of Aplastic Anemia
- 2ry
CP of Aplastic Anemia
CP of Aplastic Anemia
- hepatosplenomegaly?
Noooooo, Which Diffrentiates it From Leukemia
INvx for Aplastic Anemia
INvx for Aplastic Anemia
- PBE
INvx for Aplastic Anemia
- BM Aspiration
Aplastic marrow consists of fatty & fibrous tissue
TTT of Aplastic Anemia
TTT of Aplastic Anemia
- Causative
In secondary aplastic anemia
TTT of Aplastic Anemia
- Symptomatic
Blood, WBCs, PLT transfusion - treatment of infection
TTT of Aplastic Anemia
- Fanconi Anemia
TTT of Aplastic Anemia
- Idiopathic Anemia
- High dose IV methyl prednisolone
- Cyclosporine
- Anti-thymocyte globulin (ATG)
TTT of Aplastic Anemia
- Allogenic BM Transplantation
From an HLA matched donor → treatment of choice nowadays
