L9: Sepsis

Question 1

Def of Bactremia

Answer 1

Presence of viable bacteria in the blood

Question 2

Def of Infection

Answer 2

• A local inflammatory response to the presence of microorganisms
• or the invasion of normally sterile host tissue by those organisms

Question 3

Def of SIRS

Answer 3

Question 4

Low-grade bacteremia Vs. High-grade bacteremia

• Severity
• Lab
• Examples

Answer 4

Question 5

Def of Sepsis

Answer 5

SIRS + clinical & microbiological evidence of infection with bacteria, viruses, fungi, protozoa

Question 6

Types of Bactremia

Answer 6

Question 7

Epidemeology of Sepsis

Answer 7

Question 8

Criteria for diagnosis of SIRS

Answer 8

Question 9

Core temperature is measured by rectal, bladder, oral, or central probe

Answer 9

….

Question 10

• Tachycardia is defined as mean HR > 2 SD > normal for age
• in the absence of external stimulus, chronic drugs, or painful stimuli or otherwise, unexplained persistent elevation over 0.5 hour

Answer 10

….

Question 11

• Bradycardia is defined as a mean HR < 10th percentile for age
• in the absence of external vagal stimulus, beta-blockers, or congenital heart diseases or otherwise, unexplained persistent depression over 0.5 hour

Answer 11

….

Question 12

Grading of Sepsis

Answer 12

Question 13

Grading of Sepsis

• Uncomplicated Sepsis

Answer 13

• Presence of sepsis without manifestations of inadequate organ perfusion or function

Question 14

Grading of Sepsis

• Severe sepsis (Sepsis syndrome)

Answer 14

Question 15

Grading of Sepsis

• Early septic shock

Answer 15

◈ Sepsis syndrome + hypotension or poor capillary refill time that responds promptly to IV fluids and/or pharmacologic interventions

Question 16

Grading of Sepsis

• Refractory Septic Shock

Answer 16

◈ Sepsis syndrome + hypotension or poor capillary refill time that lasts > 1 h despite IV fluids & pharmacologic interventions and requires vasopressors

Question 17

Grading of Sepsis

• Coma

Answer 17

• ◈ Presence of altered organ function such that homeostasis cannot be maintained without intervention

Question 18

Signs of MOF

Answer 18

Question 19

Signs of MOF

• CVS

Answer 19

Question 20

Signs of MOF

• RSEP

Answer 20

Question 21

Signs of MOF

• Neurologic

Answer 21

Question 22

Signs of MOF

• Hematologic

Answer 22

Question 23

Signs of MOF

• Renal

Answer 23

Question 24

Signs of MOF

• Hepatic

Answer 24

Question 25

ICU Infections

• Classification

Answer 25

Question 26

ICU Infections

• Gram -ve

Answer 26

Question 27

ICU Infections

• Gram +ve

Answer 27

Question 28

ICU Infections

• Fungi

Answer 28

The vast majority are candidal infection

Question 29

Management of Sepsis

Answer 29

Question 30

Management of Sepsis

• Items

Answer 30

Question 31

Management of Sepsis

• Selection of specific antibiotics depends on …..

Answer 31

Question 32

Management of Sepsis

• Clinical Evcaluation

Answer 32

Question 33

Management of Sepsis

• Lab Evaluation

Answer 33

Question 34

Management of Sepsis

• TTT

Answer 34