L3: Bronchial Asthma Flashcards
Cells Responsible for acute asthma
Mast Cells
Cells Responsible for Chronic asthma
Eosinophils
Cells Responsible for Exacerbation iof Asthma
Mast Cells
Cells Responsible for Airway Remodiling
Eosinophils
Clinical clues in diagnosis of asthma
Management of Bronchial Asthma
- Determine type of patient (naรฏve or on controller)
- Determine level of control.
- 5 steps of treatment according to level of control.
Management of Bronchial Asthma
- Determine Type of Patient
Determine Type of Patient in Bronchial Asthma
- Naive
Determine Type of Patient in Bronchial Asthma
- On Controller
Determine Level of Control in Bronchial Asthma
Determine Level of Control in Bronchial Asthma
- Controlled
Determine Level of Control in Bronchial Asthma
- Partially Controlled
Determine Level of Control in Bronchial Asthma
- Uncontrolled
Duration of treatment in acute attack of Bronchial asthma
Pharmacologic TTT of Bronchial Asthma
Pharmacologic TTT of Bronchial Asthma
- Reliever (Rescue) Medications
Pharmacologic TTT of Bronchial Asthma
- Controller Medications
MOA of ICS in Bronchial Asthma
- Block late asthmatic response to allergens
- โฃโฃ airway hyper responsiveness
- โฃโฃ cytokine production
- โฃโฃ adhesion protein activation
- โฃโฃinflammatory cell migration & activation.
- Reverse ฮฒ2 receptor down regulation and sub sensitivity
MOA of Leukotriene Modifiers in Bronchial Asthma
Either 5-lipoxygenase inhibitors / leukotriene-receptor antagonists
Indications of Leukotriene Modifiers in Bronchial Asthma
They are add on therapy or alternative to steroids
MOA of Monoclonal anti-IgE Ab in Bronchial Asthma
Binds selectively to human IgE on surface of mast cells and basophils.
Indications of Monoclonal anti-IgE Ab in Bronchial Asthma
- Indicated for moderate โ severe persistent asthma in whom symptoms are not controlled by ICS
Indications of Inhaled corticosteroid in Bronchial Asthma
โ long-term control of symptoms
โ Suppression, control, and reversal of inflammation
Indications of Systemic corticosteroid in Bronchial Asthma
โ Short courses (3 โ 10 d) โ-> Control of acute asthmatic episodes
โ Long-term prevention of symptoms in severe persistent asthma
TTT of Bronchial Asthma
- Step 1
TTT of Bronchial Asthma
- Step 2
TTT of Bronchial Asthma
- Step 3
TTT of Bronchial Asthma
- Step 4
TTT of Bronchial Asthma
- Step 5
Allergen-specific Immunotherapy
Def of Asthma Exacerbation
Def of Status asthmaticus
CP of Asthma Exacerbation
CP of Asthma Exacerbation
- Common Symptoms
CP of Asthma Exacerbation
- Vitals
CP of Asthma Exacerbation
- Signs of Bronchoconstriction
CP of Asthma Exacerbation
- Increased WOB
TTT of Asthma Exacerbation
TTT of Asthma Exacerbation
- If no response
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