L3: Bronchial Asthma Flashcards

1
Q

Cells Responsible for acute asthma

A

Mast Cells

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2
Q

Cells Responsible for Chronic asthma

A

Eosinophils

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3
Q

Cells Responsible for Exacerbation iof Asthma

A

Mast Cells

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4
Q

Cells Responsible for Airway Remodiling

A

Eosinophils

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5
Q

Clinical clues in diagnosis of asthma

A
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6
Q

Management of Bronchial Asthma

A
  • Determine type of patient (naรฏve or on controller)
  • Determine level of control.
  • 5 steps of treatment according to level of control.
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7
Q

Management of Bronchial Asthma

  • Determine Type of Patient
A
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8
Q

Determine Type of Patient in Bronchial Asthma

  • Naive
A
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9
Q

Determine Type of Patient in Bronchial Asthma

  • On Controller
A
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10
Q

Determine Level of Control in Bronchial Asthma

A
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11
Q

Determine Level of Control in Bronchial Asthma

  • Controlled
A
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12
Q

Determine Level of Control in Bronchial Asthma

  • Partially Controlled
A
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13
Q

Determine Level of Control in Bronchial Asthma

  • Uncontrolled
A
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14
Q

Duration of treatment in acute attack of Bronchial asthma

A
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15
Q

Pharmacologic TTT of Bronchial Asthma

A
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16
Q

Pharmacologic TTT of Bronchial Asthma

  • Reliever (Rescue) Medications
A
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17
Q

Pharmacologic TTT of Bronchial Asthma

  • Controller Medications
18
Q

MOA of ICS in Bronchial Asthma

A
  • Block late asthmatic response to allergens
  • โ‡ฃโ‡ฃ airway hyper responsiveness
  • โ‡ฃโ‡ฃ cytokine production
  • โ‡ฃโ‡ฃ adhesion protein activation
  • โ‡ฃโ‡ฃinflammatory cell migration & activation.
  • Reverse ฮฒ2 receptor down regulation and sub sensitivity
19
Q

MOA of Leukotriene Modifiers in Bronchial Asthma

A

Either 5-lipoxygenase inhibitors / leukotriene-receptor antagonists

20
Q

Indications of Leukotriene Modifiers in Bronchial Asthma

A

They are add on therapy or alternative to steroids

21
Q

MOA of Monoclonal anti-IgE Ab in Bronchial Asthma

A

Binds selectively to human IgE on surface of mast cells and basophils.

22
Q

Indications of Monoclonal anti-IgE Ab in Bronchial Asthma

A
  • Indicated for moderate โ€“ severe persistent asthma in whom symptoms are not controlled by ICS
23
Q

Indications of Inhaled corticosteroid in Bronchial Asthma

A

โ—ˆ long-term control of symptoms

โ—ˆ Suppression, control, and reversal of inflammation

24
Q

Indications of Systemic corticosteroid in Bronchial Asthma

A

โ—ˆ Short courses (3 โ€“ 10 d) โ€”-> Control of acute asthmatic episodes

โ—ˆ Long-term prevention of symptoms in severe persistent asthma

25
Q

TTT of Bronchial Asthma

  • Step 1
26
Q

TTT of Bronchial Asthma

  • Step 2
27
Q

TTT of Bronchial Asthma

  • Step 3
28
Q

TTT of Bronchial Asthma

  • Step 4
29
Q

TTT of Bronchial Asthma

  • Step 5
30
Q

Allergen-specific Immunotherapy

31
Q

Def of Asthma Exacerbation

32
Q

Def of Status asthmaticus

33
Q

CP of Asthma Exacerbation

34
Q

CP of Asthma Exacerbation

  • Common Symptoms
35
Q

CP of Asthma Exacerbation

  • Vitals
36
Q

CP of Asthma Exacerbation

  • Signs of Bronchoconstriction
37
Q

CP of Asthma Exacerbation

  • Increased WOB
38
Q

TTT of Asthma Exacerbation

39
Q

TTT of Asthma Exacerbation

  • If no response
40
Q

Read the rest of the lecture well

A

โ€ฆ..