Infection - Hemophilus Influenza Flashcards by Ahmed Farag

Q

Causative Organism of Hemophilus Influenza

A

Hemophilus influenzae

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Q

Characters of Hemophilus Influenza

A

Gram -ve coccobacilli
Require specific growth factors for culture as hematin
Non-capsulated forms › Non-typable H. influenzae

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Q

Types of Hemophilus Influenza

A

A - F → According to the polysaccharide capsule
The most virulent is type b (95% of cases)

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Q

MOI by Hemophilus Influenza

A

Direct droplet

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Q

IP of Hemophilus Influenza

A

Variable

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Q

Age in Hemophilus Influenza

A

> 90% of cases: < 5 years
Majority: < 2 years

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Q

Host for Hemophilus Influenza

A

Only humans
A constituent of the normal respiratory flora in 60-90% of healthy children mostly non-typable

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Q

RF of invasive Disease in Hemophilus Influenza

A

Sickle cell, asplenia, immune deficiency, malignancy
Previous invasive disease

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Q

Pathogenesis of Hemophilus Influenza

A

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Q

CP of Hemophilus Influenza

A

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Q

CP of Hemophilus Influenza

M

A

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Q

CP of Hemophilus Influenza

CS

A

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Q

CP of Hemophilus Influenza

EI

A

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Q

CP of Hemophilus Influenza

PB

A

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Q

CP of Hemophilus Influenza

OSC

A

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Q

INVx for Hemophilus Influenza

A

Q

INVx for Hemophilus Influenza

Direct Smear

A

Gram stain - Methylene blue

Q

INVx for Hemophilus Influenza

CBC

A

Leukocytosis

Q

INVx for Hemophilus Influenza

Culture

A

Chocolate or blood agar

Q

INVx for Hemophilus Influenza

Serology

A

Agglutination test using antisera

Q

INVx for Hemophilus Influenza

Detection of polysaccharide Ag

A

Latex agglutination in:
- CSF
- Urine
- Blood especially in patients receiving antibiotics

Q

Prevention of Hemophilus Influenza

A

Q

Prevention of Hemophilus Influenza

Active

A

Conjugate vaccine
- Polysaccharide conjugated with protein carrier as DT toxoids outer membrane protein of N. meningitidis

Q

Prevention of Hemophilus Influenza

Passive

A

TTT of **Hemophilus Influenza**

TTT of **Hemophilus Influenza** - Moderate - Severe Sensitivity

- Ampicillin, Amoxycillin, Chloramphenicol, Cotrimoxazole (Increased resistance)

TTT of **Hemophilus Influenza** - Highest Sensitivity

* Amox-clavulanate * New macrolides (azithromycin). * 3rd generation cephalosporins

TTT of **Hemophilus Influenza** - TTT of Invasive Diseases

Invasive disease should be treated with - Appropriate parenteral antibiotics esp. cephalosporin for 7 - 14 Days