Infection - Pertussis Flashcards

1
Q

Causative Organism of Pertussis

A
  • Bordetella pertussis & Para-pertussis (Only in human)
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2
Q

Characters of Bordetella pertussis

A
  • Gram -ve coccobacilli
  • Aerobic
  • Grows on starch blood agar
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3
Q

MOI by Pertussis

A
  • Direct droplet โ€œHighly contagious with 100% attack rateโ€
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4
Q

IP by Pertussis

A
  • 3 - 12 days โ€œUp to 28 daysโ€
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5
Q

Infectivity Period for Pertussis

A
  • No therapy: 5 weeks
  • Therapy: 5 days
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6
Q

Incidence of Pertussis

A
  • 60 million cases of pertussis occur worldwide / year
  • More than 500,000 deaths
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7
Q

Age in Pertussis

A
  • The peak incidence was in children 1 - 5 year after vaccine coverage
  • Approximately 50% of cases occurs in infants < 1 year
  • 25% in adolescents and adults
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8
Q

Pathogensis of Pertussis

A
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9
Q

CP of Pertussis

A
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10
Q

CP of Pertussis

  • Catarrhal Stage
A
  • FAHM
  • ANVC
  • Rhinorrhea, lacrimation & conjunctival injection
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11
Q

CP of Pertussis

  • Paroxysmal Stage
A
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12
Q

Paroxysmal Stage of Pertussis

  • PPT by
A
  • Sneezing
  • Yawing
  • Eating
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13
Q

Paroxysmal Stage of Pertussis

  • Associated with
A
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14
Q

Paroxysmal Stage of Pertussis

  • Followed By
A
  • Loud whop (inspired air passes through partially closed airways)
  • Post-tussive exhaustion (Major clue to diagnosis)
  • Post-tussive emesis
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15
Q

CP of Pertussis

  • Convalesent Stage
A
  • During this stage the number, severity and duration of episodes diminish.
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16
Q

Pertussis in infant

  • Catarrhal Stage
  • Paroxysmal Stage
  • Convalescent Stage
17
Q

Complications of Pertussis

18
Q

Complication of Pertussis

  • Apnea
19
Q

Complication of Pertussis

  • Secondary Bacterial Infections
A
  • pneumonia and otitis media
20
Q

Complication of Pertussis

  • Encephalopathy
A
  • Apnea, intracranial hemorrhage or hypoxemia that may associate cough
21
Q

Complication of Pertussis

  • Physical Sequale of forceful cough
22
Q

Dx of Pertussis

23
Q

Dx of Pertussis

  • Clinically
24
Q

Dx of Pertussis

  • Labs
25
Q

Labs in Pertussis

  • CBC
  • Culture
  • Serology
  • Chest X-Ray
26
Q

DDx of Pertussis

27
Q

Prevention of Pertussis

28
Q

Prevention of Pertussis

  • Control
29
Q

Prevention of Pertussis

  • Prevention
A
  • Whole or better acellular pertussis vaccine.
30
Q

TTT of Pertussis

31
Q

TTT of Pertussis

  • Antimicrobials
32
Q

TTT of Pertussis

  • Salbutamol
A

May be of benefit

33
Q

TTT of Pertussis

  • Corticosteroids
A
  • No evidence of beneficial effect
34
Q

TTT of Pertussis

  • Hospitalization
35
Q

Hospitalization in TTT of Pertussis

  • Indications
36
Q

Hospitalization in TTT of Pertussis

  • Goals
37
Q

TTT of Pertussis
- Hospital Care