II - GLAUCOMA DRUGS

Question 1

<p>Acts by <strong>decreasing production of aqueous humor</strong> from ciliary epithelium</p>

Answer 1

<p><strong>Beta antagonists</strong></p>

<ul> <li>TIMOLOL (nonselective)</li> <li>LEVOBUNOLOL (nonselective)</li> <li>CARTEOLOL (nonselective)</li> <li>METIPRANOLOL (nonselective)</li> <li>BETAXOLOL (b1 selective)</li></ul>

<p><strong>Osmotic agents</strong>: Mannitol</p>

<p><strong>A2 Agonists:</strong>Brimonidine, Apraclonidine</p>

<p><strong>Carbonic anhydrase inhibitors:</strong>Acetazolamide, Dorzolamide</p>

Question 2

<p>MOA: Ciliary muscle contraction, opening of <strong>trabecular meshwork</strong> → <strong>increased outflow</strong></p>

Answer 2

<p><strong>Cholinomimetics</strong></p>

<ul> <li>Pilocarpine (Non selective muscarinic agonist)</li> <li>Physostigmine &amp; Echothiopate (Acetylcholinesterase inhibitor)</li></ul>

Question 3

<p>MOA: Increased <strong>outflow</strong> through<strong> canal of Schlemm</strong></p>

Answer 3

<p>Prostaglandin analogue:<strong>Latanoprost, Brimatoprost</strong></p>

<p></p>

Question 4

<p>Increased <strong>outflow</strong> via <strong>uveoscleral veins</strong></p>

Answer 4

<p>Non selective a agonists: <strong>Epinephrine</strong></p>