ANTIBIOTICS - ANTIPROTOZOAL Flashcards
examples of TISSUE SCHIZONTICIDES (kill schizonts in the liver)
primaquine, atovaquone
examples of BLOOD SCHIZONTICIDES
chloroquine, quinine mefloquine, atovaquone, pyrimethamine, doxycycline, halofantrine, artemisinin
example of GAMETOCIDES
primaquine
examples of SPORONTICIDES (prevent sporogony and multiplication in the mosquito)
proguanil, pyrimethamine
Side effect include Cinchonism (headache, tinnitus, vertigo), Hemolysis in G6PD deficiency, Blackwater fever
QUININE
QUINIDINE GLUCONATE
DOC for malaria in pregnant patients
Quinine
- severe complication of P. falciparum malaria
- characterized by intravascular hemolysis, massive hemoglobinuria and acute renal failure
Blackwater fever
radical cure of P. vivax, P. ovale
Terminal prophylaxis (vivax, ovale)
PRIMAQUINE
Treatment and chemoprophylaxis (chloroquine-resistant P.falciparum) - all stages
ATOVAQUONE-PROGUANIL
Common side effect is a headache without organic lesion that is Pseudotumor cerebri.
Doxycycline
Forms toxic free radicals in malarial food vacuole. Blood schizonticide.
ARTEMISININ
ARTESUNATE, ARTEMETHER, DIHYDROARTEMISININ
the drug of choice for uncomplicated falciparum malaria in the Philippines
Artemether-Lumefantrine (Co-Artem)
DOC for Chloroquine sensitive P. falciparum
Chloroquine
DOC for P. vivax and P. ovale
Chloroquine then Primaquine