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#‼️PHARMACOLOGY > CNS DRUGS - SKELETAL MUSCLE RELAXANTS > Flashcards

CNS DRUGS - SKELETAL MUSCLE RELAXANTS Flashcards

1
Q

NONDEPOLARIZING NEUROMUSCULAR BLOCKERS

A

TUBOCURARINE [C] MIVACURIUM [C] ATRACURIUM [C] VECURONIUM [C] ROCURONIUM [C] PANCURONIUM [C]

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2
Q

long acting Nondepolarizing neuromuscular blocker

A

TUBOCURARINE [C]

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3
Q

what will you give to reverse effects of NONDEPOLARIZING NEUROMUSCULAR BLOCKERS

A

NEOSTIGMINE

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4
Q

SHORT acting Nondepolarizing neuromuscular blocker

A

MIVACURIUM

* MI- MI- MIdget! Mivacurium! bansot! Short acting. hehez

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5
Q

ISOQUINOLINE Nondepolarizing neuromuscular blocker

A

MIVACURIUM ATRACURIUM

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6
Q

Nondepolarizing neuromuscular blocker metabolized by pseudocholinesterase

A

MIVACURIUM

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7
Q

INTERMEDIATE acting Nondepolarizing neuromuscular blocker

A

ATRACURIUM CISATRACURIUM

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8
Q

Both atracurium and Cisatracurium undergo what kind of ELIMINATION?

A

Hoffman elimination (rapid spontaneous breakdown) yielding Laudanosine (seizure causing)

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9
Q

NMBs considered as DOC for hemodynamically compromised patients (less chances for histamine release causing hypotension)

A

Cisatracurium, vecuronium and rocuronium

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10
Q

AMINOSTEROID Nondepolarizing neuromuscular blocker

A

VECURONIUM [C] ROCURONIUM [C] PANCURONIUM [C]

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11
Q

A novel reversal agent specifically for rocuronium (but can also reverse vecuronium and pancuronium to a lesser extent

A

SUGAMMADEX

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12
Q

Long acting NMB

A

PANCURONIUM [C]

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13
Q

NMB used for Euthanasia, Lethal injection, Strychnine poisoning

A

PANCURONIUM [C]

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14
Q

What are the drugs used in lethal injection?

A

• Thiopental (5 g) • Pancuronium (100 mg) • Potassium chloride (100 mEq)

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15
Q

Phases of Depolarizing Blockade

A

• PHASE I (DEPOLARIZATION) o membrane depolarizes w/ initial electric discharge o transient fasciculations followed by flaccid paralysis • PHASE II (DESENSITIZATION) o membrane repolarizes but receptor is desensitized to the effects of acetylcholine

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16
Q

NMB of choice for rapid sequence induction

A

SUCCINYLCHOLINE [C]

17
Q

Metabolized by Pseudocholinesterase (just like Mivacurium)

A

SUCCINYLCHOLINE [C]

18
Q

rare interaction of succinylcholine (and possibly tubocurarine) with inhaled anesthetics (halothane)

A

MALIGNANT HYPERTHERMIA

19
Q

early sign of MALIGNANT HYPERTHERMIA

A

contraction of jaw muscles (trismus)

20
Q

antidote for Malignant hyperthermia

A

Dantrolene

21
Q

CENTRALLY ACTING SPASMOLYTIC DRUG

A

BACLOFEN [C]

22
Q

MOA of dantrolene

A

Block RyR1 Ca 2+ -release channels in the sarcoplasmic reticulum of the skeletal muscle

#‼️PHARMACOLOGY (31 decks)

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