CNS DRUGS - SKELETAL MUSCLE RELAXANTS

Question 1

NONDEPOLARIZING NEUROMUSCULAR BLOCKERS

Answer 1

TUBOCURARINE [C] MIVACURIUM [C] ATRACURIUM [C] VECURONIUM [C] ROCURONIUM [C] PANCURONIUM [C]

Question 2

long acting Nondepolarizing neuromuscular blocker

Answer 2

TUBOCURARINE [C]

Question 3

what will you give to reverse effects of NONDEPOLARIZING NEUROMUSCULAR BLOCKERS

Answer 3

NEOSTIGMINE

Question 4

SHORT acting Nondepolarizing neuromuscular blocker

Answer 4

MIVACURIUM

* MI- MI- MIdget! Mivacurium! bansot! Short acting. hehez

Question 5

ISOQUINOLINE Nondepolarizing neuromuscular blocker

Answer 5

MIVACURIUM ATRACURIUM

Question 6

Nondepolarizing neuromuscular blocker metabolized by pseudocholinesterase

Answer 6

MIVACURIUM

Question 7

INTERMEDIATE acting Nondepolarizing neuromuscular blocker

Answer 7

ATRACURIUM CISATRACURIUM

Question 8

Both atracurium and Cisatracurium undergo what kind of ELIMINATION?

Answer 8

Hoffman elimination (rapid spontaneous breakdown) yielding Laudanosine (seizure causing)

Question 9

NMBs considered as DOC for hemodynamically compromised patients (less chances for histamine release causing hypotension)

Answer 9

Cisatracurium, vecuronium and rocuronium

Question 10

AMINOSTEROID Nondepolarizing neuromuscular blocker

Answer 10

VECURONIUM [C] ROCURONIUM [C] PANCURONIUM [C]

Question 11

A novel reversal agent specifically for rocuronium (but can also reverse vecuronium and pancuronium to a lesser extent

Answer 11

SUGAMMADEX

Question 12

Long acting NMB

Answer 12

PANCURONIUM [C]

Question 13

NMB used for Euthanasia, Lethal injection, Strychnine poisoning

Answer 13

PANCURONIUM [C]

Question 14

What are the drugs used in lethal injection?

Answer 14

• Thiopental (5 g) • Pancuronium (100 mg) • Potassium chloride (100 mEq)

Question 15

Phases of Depolarizing Blockade

Answer 15

• PHASE I (DEPOLARIZATION) o membrane depolarizes w/ initial electric discharge o transient fasciculations followed by flaccid paralysis • PHASE II (DESENSITIZATION) o membrane repolarizes but receptor is desensitized to the effects of acetylcholine

Question 16

NMB of choice for rapid sequence induction

Answer 16

SUCCINYLCHOLINE [C]

Question 17

Metabolized by Pseudocholinesterase (just like Mivacurium)

Answer 17

SUCCINYLCHOLINE [C]

Question 18

rare interaction of succinylcholine (and possibly tubocurarine) with inhaled anesthetics (halothane)

Answer 18

MALIGNANT HYPERTHERMIA

Question 19

early sign of MALIGNANT HYPERTHERMIA

Answer 19

contraction of jaw muscles (trismus)

Question 20

antidote for Malignant hyperthermia

Answer 20

Dantrolene

Question 21

CENTRALLY ACTING SPASMOLYTIC DRUG

Answer 21

BACLOFEN [C]

Question 22

MOA of dantrolene

Answer 22

Block RyR1 Ca 2+ -release channels in the sarcoplasmic reticulum of the skeletal muscle