ANTIBIOTICS - ANTIFUNGALS

Question 1

MOA: Binds to ergosterol in fungal cell membranes, forming artificial pores. Fungicidal.

Answer 1

AMPHOTERICIN B

Question 2

Has the WIDEST antifungal spectrum

Answer 2

AMPHOTERICIN B

Question 3

used for fungal MENINGITIS

Answer 3

FLUCYTOSINE

Question 4

Most common and most serious long term toxicity of AMPHOTERICIN B

Answer 4

NEPHROTOXICITY

Question 5

Non-competitive inhibitor of THYMIDILATE SYNTHASE

Answer 5

FLUCYTOSINE

Question 6

Blocks biosynthesis of ERGOSTEROL

Answer 6

Azoles

Question 7

BROADEST spectrum triazole (the only azole with activity against Rhizopus sp. (mucormycosis)

Answer 7

POSACONAZOLE

Question 8

MOA: Inhibits b-glucan synthase decreasing fungal cell wall synthesis

Answer 8

CASPOFUNGIN [C]

ANIDULAFUNGIN, MICAFUNGIN

(ECHINOCANDIN)

Question 9

MOA: Interferes with MICROTUBULE FUNCTION.

Answer 9

GRISEOFULVIN

Question 10

Griseofulvin is best absorbed with _____ meal.

Answer 10

Fatty Meal

Question 11

MOA: Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase. Fungicidal.

Answer 11

TERBINAFINE

BUTENAFINE, NAFTIFINE

Question 12

Ketoconazole is better absorbed with _______

Answer 12

Acidic gastric environment

Question 13

high doses of ketoconazole cause significant _____

Answer 13

REDUCTION IN TESTOSTERONE SYNTHESIS

Question 14

Azole of choice in the TREATMENT AND PROPHYLAXIS of CRYPTOCOCCAL MENINGITIS

Answer 14

FLUCONAZOLE

Question 15

DOC for paracoccidioidomycosis and chromomycosis

Answer 15

Itraconazole